阿片类药物成瘾者基于杏仁核的Resting-state fMRI研究

Resting State fMRI Study of Amygdala in Opioid Addiction

目的通过Resting-state fMRI探讨阿片类药物对杏仁核功能连接的影响。资料与方法阿片类药物成瘾患者12例,健康被试者14名(均为男性)。采用3.0 T磁共振扫描仪,对被试者分别进行静息态功能磁共振扫描,以双侧杏仁核为感兴趣区,分别进行功能连接分析,再将左右侧差异性脑区与阿片类药物成瘾组总吸毒时间、平均每日吸毒量等作相关分析。结果与对照组比较,阿片类药物成瘾者杏仁核与双侧海马旁回及双侧小脑半球功能连接度显著增强,与双侧楔前叶,左侧颞中、下回,左侧额中回功能连接度显著下降;左侧杏仁核和右侧楔前叶的功能连接度与阿片类成瘾者每日吸入量呈负相关。结论阿片类药物成瘾者认知控制功能的神经环路受损,而奖赏以及学习记忆环路功能出现异常强化。

Objective To discuss opioid effects on amygdala function connection by resting state fMRI.Materials and Methods Opioid addiction 12 patients and 14 healthy subjects（all men） received resting state functional MRI,the bilateral amygdala were used as regions of interest respectively to analyze functional connectivity,the difference between left and right side of the brain regions with opioids and the total time of drug addiction,such as average daily volume of drug were analyzed.Results Compared with the control group,connectivity of opiate addicts bilateral parahippocampal gyrus,amygdala and bilateral cerebellar hemisphere was significantly enhanced,and connectivity of two sided precuneus,left temporal lobe and the left middle frontal gyrus functional was significantly decreased,connectivity degree of the left amygdala and right precuneus was negative to average daily volume of opioid.Conclusion Opioid addicts cognitive control function of neural circuits is damaged,and rewarded,loops of learning and memory function is strengthened.