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Ⅲ型磷脂酰肌醇3-激酶复合物与自噬的研究进展 被引量：7

Advances in Relationship Between Class Ⅲ PI3K Complex and Autophagy
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摘要 Ⅲ型磷脂酰肌醇3-激酶(classⅢPI3K)是以磷脂酰肌醇(PtdIns)为底物催化产生PtdIns3 P的激酶,与多种不同的调节蛋白结合形成Ⅲ型PI3K(PI3KC3)复合物,在自噬及膜泡运输中起重要作用.PI3KC3复合物组成成员PI(3)KC3、p150、Beclin 1、ATG14L、UVRAG、Bif-1和Rubicon在进化上大多具有高度的同源性和保守性,并且与神经系统发育、胸腹腔内脏反位及肿瘤等多种疾病的发生和发展密切相关. Class Ⅲ phosphoinositide 3-kinase（class Ⅲ PI3K）,which specifically phosphorylate PtdIns to generate PtdIns3P,plays a vital role in autophagy and vacuolar sorting pathways by forming Class Ⅲ PI3K（PI3KC3） complexes with a variety of regulatory proteins.Proteins that compose PI3KC3 complex,namely,PI3K,p150,Beclin 1,ATG14L,UVRAG,Bif-1 and Rubicon are conserved in evolution.In addition,neurodevelopment,situs inversus totalis and development of tumor are found to closely related to these members.
作者 吴葩 许彩民
机构地区 中国医学科学院基础医学研究所
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2012年第3期210-216,共7页 Progress In Biochemistry and Biophysics
基金 国家自然科学基金(30770491,30970655) 国家重点实验室课题(2060204) 国家教委博士点基金(20091106110025)资助项目~~
关键词 磷脂酰肌醇3-激酶 PI3KC3复合物 Vps34 自噬 phosphoinositide 3-kinase PI3KC3 Vps34 autophagy
分类号 Q291 [生物学—细胞生物学]
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共引文献163

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生物化学与生物物理进展
2012年 第3期

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