HPV和肺癌关系的研究进展

Study Advance of Relationship between HPV and Lung Cancer

肺癌是严重危害人类健康的恶性肿瘤之一,近50年来其发病率和死亡率呈现不断上升趋势,肺癌的发病率和死亡率在世界范围内均居各种癌症首位。肺癌的危险因素是多方面的。吸烟是其中一个重要风险因素,但不吸烟者(特别是女性)仍有一部分会患肺癌。许多研究认为人类乳头瘤病毒(human papillomavirus,HPV)是肺癌的危险因素。然而,HPV作为肺癌的风险因素,对其进行的全面认真的评估较少。由于检测方法、地区分布、样本量等存在差异造成HPV感染和肺癌的相关性研究结果也不尽相同。近年来,随着研究的不断深入,HPV与肺癌的关系日益受到重视。现将近年关于HPV和肺癌关系的研究进展作一简要综述。

Lung cancer is one of malignant tumors harming human health.Over the past five decades,there is in-creasing morbidity and mortality of lung cancer which is the leading cause of cancer morbidity and mortality worldwide.Risk factors of lung cancer are versatile and smoking is among the important ones,but there are some non-smoking men,especially for women,some of whom developed lung cancer.Many studies showed that human papillomavirus（HPV）was the risk factor of lung cancer,however,which was less comprehensive or seriously estimated.The results of research on relationship between HPV infection and lung cancer are different because of the difference of detection methods,geographical distribution and sample size.Recently,the relationship of HPV and lung cancer is increasingly thought highly with deep study.Study advance of relationship between HPV and lung cancer in the recent years is briefly reviewed.