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(E)-4-吗啉-2-丁烯酸盐酸盐的合成

Synthesis of(E)-4-morpholine-2-butenoic acid hydrochloride
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摘要 以吗啉为起始原料,与溴丁烯酸甲酯反应,得到4-吗啉-2-丁烯酸甲酯,然后在二氧六环中用浓盐酸水解,得到目标产物,总收率为49.65%,产物结构经过1H NMR确证。 （E）-4-morpholine-2-butenoic acid hydrochloride was synthesized from morpholine and 4-bromo-2-butenoic acid methyl ester obtained from 4-morpholine methyl crotonate.Then it was hydrolysised by hydrochloric acid in dioxane.The overall yield of target product was 49.65%.The product was characterized by 1H NMR spectrometry.
作者 景梦梦 王尧斌 雷美娟 邱方利
机构地区 台州学院医药化工系
出处 《应用化工》 CAS CSCD 2012年第2期212-213,216,共3页 Applied Chemical Industry
基金 国家自然科学基金资助项目(21106090)
关键词 (E)-4-吗啉-2-丁烯酸盐酸盐 吗啉 4-溴丁烯酸甲酯 合成 （E）-4-morpholine-2-butenoic acid hydrochloride morpholine 4-bromo-2-butenoic acid methyl ester synthesis
分类号 TQ463.5 [化学工程—制药化工]
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参考文献8

  • 1Diane H Boschelli,Wang Daniel,Wang Yan,et al.Optimi-zation of 7-alkene-3-quinolinecarbonitriles as srckinase in-hibitors[J].Bioorganic&Medicinal Chemistry Letters,2010(20):2924-2927.
  • 2Christopher W Murray,Maria G Carr,Owen Callaghan,et al.Fragment-based drug discovery applied to Hsp 90.discovery of two lead series with high ligand efficiency[J].J Med Chem,2010(53):5942-5955.
  • 3陈冬梅,张雁芳,杨日芳,汪海.吗啉环和哌嗪环类新衍生物对血管舒张功能的影响[J].中国药理学通报,2003,19(7):754-758. 被引量：8
  • 4Edwin Andres Correa,Edward D Hogestatt,Olov Sterner,et al.In vitro TRPV1 activity of piperine derived amides[J].Bioorganic&Medicinal Chemistry,2010(18):3299-3306.
  • 5马楠,王筱平,柯桢,张道虹.N-Boc-(S)-二羟甲基吗啉的合成研究[J].化学试剂,2009,31(8):595-597. 被引量：1
  • 6Scott E Denmark,Tetsuya Kobayashi,Christopher S Re-gens.Total synthesis of(+)-papulacandin D[J].Tetra-hedron,2010(66):4745-4759.
  • 7Erik L Meremereredith,Kimberly Beattie,Bobin Burgis,etal.Identification of potent and selective amidobipyridyl in-hibitors of protein kinase D[J].J Med Chem,2010(53):5422-5438.
  • 8Sampath-Kumaranandan,Richard D Gless.Exploration ofsecondary and tertiary pharmacophores in unsymmetricalN,N’-diaryl urea inhibitors of soluble epoxide hydrolase[J].Bioorganic&Medicinal Chemistry Letters,2010(20):2740-2744.

二级参考文献12

  • 1GREENWOOD D T, MALLION K B, TODD A H, et al. 2- Aryloxymethyl-2,3,5,6-tetrahydro-1,4-oxazines,a new class of antidepressants [ J]. J. Med. Chem. , 1975,18 : 573.
  • 2GUO H Y,LORENZ R R,VERBEUREN T J,et al. Effects of S-11701 on allumulation, release and metabolism of norepinephrine in isolated canine saphenous veins[J]. Gernal Pharmacology, 1992,23(6) : 1 079-1 085.
  • 3BRENNER E, BALDWIN R M, TAMAGNAN G. Asymmeteic synthesis of ( + )-( S, S)-reboxetine ria a new (S)-2-(hydroxymethyl) morpholine preparation [ J]. Org. Lett., 2005, 7:937-939.
  • 4Sankyo Co. , Ltd., Japan. Patent, JP03-130 282. Cumarine derivatine[ J] . Chem. Abstr. , 1991,115:71 396.
  • 5WAGLE D R, MONTELEONE M G. Novel synthesis of optically active morpholines[J]. Chem. Soc. , Chem. Commun. , 1989:915-916.
  • 6BENNIS K, CALINAUD P, JACQUES G. A new route to some enantiomerically pure substituted morpholines from D-ribono and D-gulono-1,4-lactones [ J ] . J. Carbohydr. Res. , 1994, 264:33-44.
  • 7LAINTON J A H,ALLEN M C,BURTON M.Design and synthesis of a diverse morpholine template library [ J ]. Comb. Chem. , 2003,5:400-407.
  • 8WILKINSON M C. Asymmetric synthesis of an aminomethyl morpholine via double allylic substitution [ J ]. Tetrahedron Lett. ,2005, (46):4 773-4 775.
  • 9PORZI G. Synthesis of uncommon tripeptides derived from 2,6-diaminopimelic acid [ J ] . Tetrahedron : Asymmetry, 2001, 12:3 319-3 324.
  • 10JEAN-CHARLES Q, HENRI-PHILIPPE H. Stereoselective synthesis of 2, 6-disub stituted morpholines from chiral non- racemic lactams[J]. Tetrahedron Lett. ,1999,40:7 227-7 230.

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2012年 第2期

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