替米考星交联淀粉载药微球的制备研究

Study on synthesis of tilmicosin crosslinked starch microspheres

以可溶性淀粉为原料,采用反相悬浮聚合法,合成了替米考星淀粉交联共聚载药微球。探讨了投药量、反应时间、交联剂、乳化剂对替米考星淀粉微球载药量、包封率和微球形貌的影响,运用红外、热重、电镜、粒度分析仪对产物进行了表征。结果表明,最佳制备条件为:替米考星0.02 g,淀粉4 g,乳化剂0.75 g,交联剂0.95 g,反应1.5 h,合成的替米考星淀粉微球载药量2.43%,包封率88.6%。微球粒径分布均匀,外观圆整,表面粗糙,具有较好的热稳定性。

Tilmicosin crosslinked starch microspheres（T-CSMs） were synthesized with soluble starch as material by reversed phrase suspension method.The effects of the quantity of tilmicosin,reaction time,crosslinking agent dosage and emulsifying agent dosage on the loading of drug,the incorporation rate and the T-CSMs shape were studied.Fourier transform infrared spectroscopy（IR）,thermogravimetric analysis（TG）,scanning electron microscopy（SEM） and granularity analyzer were used to characterize cationic starch microsphere.The results showed that the proper synthesis conditions were：the quantity of tilmicosin,the quantity of soluble starch,rosslinking agent dosage,emulsifying agent dosage and reaction time,were 0.02,4,0.95,0.75 g,1.5 h,respectively.The loading of drug and the incorporation rate of the synthetic T-CSMs according to the best conditions were 2.43% and 88.6%,and size distribution of T-CSMs was uniform,appearance was roundness,and good thermal stability.