双丙酮丙烯酰胺与海藻酸钠接枝聚合制备双亲性药物载体

Synthesis of amphiphilic block copolymer via graft polymerization of DAAM and SA

双丙酮丙烯酰胺(DAAM)与海藻酸钠(SA)进行接枝聚合反应,过硫酸钾作为引发剂,制备了海藻酸钠-双丙酮丙烯酰胺两亲性共聚物,接枝率可以达到43%,该产物在水相中发生自聚集,形成直径300～500 nm的胶束。用红外光谱(FTIR)、热重分析(TGA)、荧光光谱(FS)、元素分析(EA)、扫描电镜(SEM)和Zeta电位对产物进行了表征。结果表明,胶体粒子表面带负电荷,在水中分散,结构稳定。将其用钙离子交联后形成凝胶,对于模型药物布洛芬(ibuprofen)有较好的负载率和缓释行为,载药率可以达到12%。

Amphiphilic DAAM-SA block copolymer was synthesized via graft polymerization of DAAM and SA with potassium persulfate as initiator,the grafting rate can reach 43%.Through self-assembly in water phase,the product can be formed a micelle with diameter of 300～500 nm.The products were characterized by FTIR,TGA,FS,EA,SEM and Zeta potential analysis.The results showed that the negatively charged micelles can be well dispersed and stabilized in water.Then the products cross-linked with calcium ions to form gelatin,which can control the loading and release behavior of model drug ibuprofen,the drug-loading rates was up to 12%.