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房颤患者血浆NT-proBNP水平临床分析 被引量：2

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摘要 脑钠肽（brainnatriureticpeptide,BNP）是由日本Sudoh[1]等人于1988年在猪脑中发现的含32个氨基酸的多肽,当心室扩张或容量负荷过重时分泌增加。氨基末端脑钠肽前体（NT-proBNP）是BNP的前体肽链结构的N末端产物,和BNP是等摩尔分泌的,但比BNP更稳定、半衰期更长,临床易于检测[2]。心功能下降时BNP合成释放增加,同时NT-proBNP浓度增加。房颤会造成有效的心房收缩丧失,
作者 赵宏伟
机构地区 浙江省绍兴市第七人民医院
出处 《浙江中西医结合杂志》 2012年第3期199-200,共2页 Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
关键词 房颤 NT-PROBNP 心功能
分类号 R541.75 [医药卫生—心血管疾病]
  • 相关文献

参考文献4

  • 1Sudoh T,Kangawa K,Minamino N,et al.Anew natriuretic peptide inporeine brain[J].Nature,1988,332:78-81.
  • 2Balion c,Santaguida PL,Hill S,et al.Testing for BNP and NT-proBNP in the diagnosis and prognosis of heart failure[J].Evid Rep Technol Assess(FuⅡRep),2006,(142):1-147.
  • 3Maisel AS,Krishnaswamy P,Nowak RM,et al.Rapid mea-surement of B-type natriuretic peptide in the emergency diagnosis of heart failure[J].N Engl J Med,2002,347:161-167.
  • 4高晓峰,李占荣,王希章,周青,王淑春,王志敏,赵俊琴.高血压伴心房颤动患者血浆N末端脑钠肽原浓度分析[J].山西医药杂志（上半月）,2009,38(2):151-152. 被引量：3

二级参考文献5

  • 1Cheung BM,Kumana CR.Natriuretic peptides-relevance in cardiovascular disease[].The Journal of The American Medical Association.1998
  • 2MAIRJ,HAMMERERLERCHERA,PUSCHENDORFB.Theimpact ofcardiacnatriureticpeptidedeterminationonthediagnosisandman agementofheartfailure[].ClinChemLabMed.2001
  • 3Maisel AS,Krishnaswamy P,Nowak RM,et al.Rapid measurementof B-type natriuretic peptide in the emergency diagnosis of heart fail-ure[].The New England Journal of Medicine.2002
  • 4Inoue S,Murakami Y,Sano K, et al.Atrium as a source of brain natriuretic polypeptide in patients with atrial fibrillation[].Journal of Cardiac Failure.2000
  • 5Tuinenburg,AE,Brundel,BJ,Van Gelder,IC,Henning,RH,Van Den Berg,MP,Driessen,C,Grandjean,JG,Van Gilst,WH,Crijns,HJ.Gene expression of the natriuretic peptide system in atrial tissue of patients with paroxysmal and persistent atrial fibrillation[].Journal of Cardiovascular Electrophysiology.1999

共引文献2

同被引文献31

  • 1周京敏,周俊,潘文志,郝颖,金雪娟,刘少稳,蔡乃绳,葛均波.左室收缩功能正常的心房颤动患者血清NT-pro-BNP水平的变化及影响因素探讨[J].中国临床医学,2007,14(2):129-131. 被引量：13
  • 2Shelton RJ,Clark AL,Goode K,et al.The diagnostic utility of N-terminal pro-B-type natriuretic peptide for the detection of major structural heart disease in patients with atrial fibrillation[J] .Eur Heart J,2006,27(19):2353-2361.
  • 3Shin DI,Jaekel K,Schley PH,et al.Plasma levels of NT-pro-BNP in patients with atrial fibrillation before and after electrical cardioversion[J] .Z Kardiol,2005,94:795-800.
  • 4Kallergis EM,Manios EG,Kanoupakis EM,et al.Effect of sinus rhythm restoration after electrical cardioversion on apelin and brain natriuretic Peptide prohormone levels in patients with persistent atrial fibrillation[J] .Am J Cardiol,2010,105 (1):90-94.
  • 5Do(g)an A,Gedikli O,Ozaydin M,et al.Plasma renin activity and pro-B-type natriuretic peptide levels in different atrial fibrillation types[J] .Anadolu Kardiyol Derg,2010,10 (4):317-22.
  • 6黎伟强.N末端前B型利钠肽与房颤伴快心室反应的关系[J] .医药前沿,2012(35):219-220.
  • 7Solheim E,Off MK,Hoff PI,et al.N-terminal pro-B-type natriuretic peptide level at long-term follow-up after atrial fibrillation ablation:a marker of reverse atrial remodelling and successful ablation[J] .J Interv Card Electrophysiol,2012,34 (2):129-36.
  • 8Higa C,Ciambrone G,Donato MS,et al.NT-Pro-BNP levels performance before and after reversion to sinus rhythm in patients with preserved ventricular function[J] .Medicina (B Aires),2011,71(2):146-150.
  • 9Fonseca AC,Brito D,Pinho E,et al.N-terminal pro-brain natriuretic peptide shows diagnostic accuracy for detecting atrial fibrillation in cryptogenic stroke patients[J] .Int J Stroke,2013,26:111-116.
  • 10Sanna T,Sonaglioni A,Pieroni M,et al.Baseline NT-Pro-BNP levels and arrhythmia recurrence in outpatients undergoing elective cardioversion of persistent atrial fibrillation:a survival analysis[J] .Indian Pacing Electrophysiol J,2009,9 (1):15-24.

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浙江中西医结合杂志
2012年 第3期

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