出生体质量与儿童代谢综合征的相关性

The relationship between birth weight and metabolic syndrome in children

代谢综合征(metabolic syndrome,MetS)是中心性肥胖、糖耐量异常、高血压、高三酰甘油血症和低高密度脂蛋白胆固醇血症等代谢紊乱症候群。研究显示,出生体质量异常新生儿在成年期发生代谢性疾病的概率大于出生体质量正常者。出生体质量异常可能会导致儿童及成年期一系列代谢性改变,但目前对于巨大儿及低出生体质量儿发展为儿童代谢综合征的机制还处于探索阶段。与此同时,很多实验研究各自采用不同的儿童代谢综合征的定义,因而难以对这些实验结论做出直接横向比较。文章将分别阐述出生体质量异常与儿童代谢综合征各组分相关性研究进展。

The metabolic syndrome（MetS）is a cluster of cardiovascular risk factors defined by the co-occurrence of at least 3 of the following features：obesity,hyperglycemia,hypertension,hypertriglyceridemia,and low high-density lipoprotein（HDL）cholesterol level.Clinical studies have shown that abnormal birth weight may cause lots of metabolic changes in children and elders.However,the specific mechanism is still unknown.It is difficult to compare the conclusions drawn by different research groups because different MetS definitions are used for children.The relationship between abnormal birth weight and MetS in children was reviewed in this paper.