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凋亡细胞清除机制在动脉粥样硬化中的研究进展 被引量：2

Research Advances in Atherosclerosis of Removal Mechanisms of Apoptotic Cells
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摘要 目的了解凋亡细胞清除机制在动脉粥样硬化中的研究进展。方法对国内、外有关研究凋亡细胞清除机制在动脉粥样硬化中的作用的文献进行综述。结果凋亡细胞清除因子转谷氨酰胺酶2、乳脂肪球表皮生长因子8、补体系统、c-Mer原癌基因酪氨酸激酶及Fas清除缺陷导致动脉粥样硬化斑块脂质核心的形成。结论吞噬凋亡细胞受体的丰余性如何消除及研究其受体下游信号的共同通路是今后的发展方向。 Objective To review research advances in atherosclerosis of removal mechanisms of apoptotic cells.MethodThe literatures about the removal mechanisms of the apoptotic cells were reviewed.ResultsThe removal factors of apoptotic cells,such as transglutaminase 2,milk fat globule-EGF-factor 8,complement system,c-Mer proto-oncogene tyrosine protein kinase,and Fas,might cause the lipid core of the atherosclerotic plaque if one of them was defective phagocytic clearance.ConclusionHow to remove the surplus of the phagocytosis and study the common pathways of the downstream signal of its receptor were the future direction of development.
作者 汪海飞 陈开 郑江华
机构地区 川北医学院附属医院血管外科
出处 《中国普外基础与临床杂志》 CAS 2012年第2期224-227,共4页 Chinese Journal of Bases and Clinics In General Surgery
关键词 凋亡细胞 动脉粥样硬化 Apoptotic cell Atherosclerosis
分类号 R543.5 [医药卫生—心血管疾病]
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参考文献35

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二级参考文献3

共引文献19

同被引文献23

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中国普外基础与临床杂志
2012年 第2期

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