合成对乙酰氨基酚动力学的研究

Study on the Kinetics of Synthesis Reaction of p-Acylaminophenol

采用间歇搅拌反应釜 ,在反应温度 60～ 80℃、氢压 0 2～ 1 .6MPa、对硝基酚初始浓度 0 4 1 4～ 3 .3 1 1mol/L条件下 ,研究了一步合成对乙酰氨基酚的总反应动力学行为。结果表明 ,温度对总反应有明显影响。按照经验模型 ,回归的总反应动力学方程式为 :R0 =1 .6× 1 0 8·exp( -68.9× 1 0 3/RT)·p0 .

The kinetic behaviors of the preparation reaction of p-acylaminophenol (APAP) was investigated in a bathwise stirred reactor at 60～180 ℃,and under H 2 pressure 0.2 ～ 1.6 MPa,and the initial concentration of p-nitrophenol(PNP) 0.414 ～ 3.311 mol/L.The results show that the temperature of the reaction has great effect on the initial reaction rate.The experimental data were regressed by means of the empirical models,the equation of the kinetics is pressented as follows: R 0=1.6×10 8·exp(-68.9×10 3/RT)·p 0.8