4种常用驱梅药物治疗早期梅毒的疗效评价

Therapeutic efficacy of four commonly used medicines for early syphilis

梅毒是由梅毒螺旋体(TP)感染引起的一种慢性性传播疾病。近年来,由于其发病率的增加与广泛的传播,以及对人体造成的巨大危害性,梅毒治疗的有效性成为人们日益关注的问题。半个多世纪以来,青霉素一直是治疗梅毒的首选药物,然而随着对青霉素过敏的个体出现与其治疗局限性,以及对阿奇霉素耐药梅毒螺旋体出现后,寻求等效的替代方案成为治疗梅毒的重要手段。本文对青霉素、头孢曲松、米诺环素和阿奇霉素这4种临床常用的驱梅药物治疗早期霉毒的疗效评价进行综述。

Syphilis is a kind of chronic sexually transmitted disease caused by treponema pallidum （TP）. In recent years, there has been more and more concern over syphilis due to its increasing incidences, widespread prevalence as well as its tremen- dous harm to people. Penicillin has been the first choice for treating syphilis since half a century ago. However, it is necessary to find alternative therapy with equivalent efficacy as Treponema pallidum develops resistance to azithromycin and some individuals are allergic to penicillin. This article reviews on the therapeutic efficacies of four commonly used medicines （ penicillin, ceftriax- one,minocycline and azithromycin） in treating primary syphilis.