龙岗区常用抗菌药物用量与鲍曼不动杆菌耐药率的相关性探讨

The relationship between antimicrobial consumption and the rates of resistance of acinetobacter baumannii

目的探讨深圳市龙岗区常用抗菌药物用量与鲍曼不动杆菌耐药率的相关性。方法统计2005～2010年深圳市龙岗区五间二甲医院26种常用抗菌药物平均每日每百张床位所消耗的DDDs及各类标本培养的鲍曼不动杆菌的耐药率,并对抗菌药物用量与耐药率进行相关性分析。结果鲍曼不动杆菌对氨苄西林、头孢唑啉、头孢吡肟、头孢他啶、头孢曲松、庆大霉素、环丙沙星、左氧氟沙星耐药率相对较高,均超过50%;对妥布霉素、亚胺培南西司他丁钠、阿米卡星的耐药率相对较低,但对亚胺培南西司他丁钠耐药率最高时也达40.5%。鲍曼不动杆菌对氨苄西林、头孢他啶、头孢曲松、环丙沙星、左氧氟沙星、亚胺培南西司他丁、复方新诺明、阿米卡星等的耐药率部分抗生素的用量正相关(P<0.05或P<0.01)。结论常用抗菌药物用量与鲍曼不动杆菌对抗菌药物的耐药水平之间存在正相关关系。

Objective To investigate the relationship between the consumption of antibacterial agents and resistance rate of acinetobacter baumannii （Ab） in the hospital. Methods The total antibacterial consumption, which were from 2005 to 2010 in 5 hospital of Longgang district, were expressed as defined daily doses （DDD）/day/100 bed, as well as the resistance rate of Ab were collected, and their correlation was analyzed. Results The resistance rate of Ab to Ampicillin, Ceftazidime, Ceftriaxone, Ciprofloxacin, Levofloxacin, Imipenem and Cilastatin, Compound Sulfamethoxazole, Amikacin were significantly positively associated with the consumption of most of antibacterial agents. Conclusion There is a positive correlation between the yearly antimicrobial consumption and the resistance rate of Ab.