HIF-1α在卵巢癌中的表达及与化疗耐药相关性研究

Analysis of the Relationship between HIF-1αgene Expression and Drug Resistance of Chemotherapy in Ovarian Cancer

目的:探讨缺氧诱导因子-1α(HIF-1α)在卵巢癌中的表达及其在卵巢癌化疗耐药中的作用。方法:采用免疫组化方法,检测96例卵巢癌组织,45例良性卵巢肿瘤和30例正常卵巢组织中HIF-1α的表达,分析其表达与临床病理特征及化疗耐药的相关性。结果:卵巢癌中HIF-1α的表达高于正常卵巢及良性卵巢肿瘤组织,且临床分期越晚其表达越高(P<0.001),而与肿瘤组织类型、病理分级及患者年龄无显著相关性。HIF-1α在卵巢癌化疗耐药组阳性率明显高于化疗敏感组(P<0.001)。结论:卵巢癌中HIF-1α高表达与卵巢癌的发生、发展、浸润和转移有关,与卵巢癌化疗耐药密切相关,HIF-1α可成为卵巢癌化疗新的分子治疗靶点。

Objective： To investigate the expression of HIF-1α in ovarian cancer and its the relationship with chemotherapy drug resistance.Methods： The expression of HIF-1α in ovarian tumours was detected and the results in related with drug resistance was studied.Results： The expression of HIF-1α in ovarian cancer positive rate was higher than that in normal tissues and benign tumours（P〈0.001）.The expression of HIF-1α and FIGO stage were relevant（P0.001）.The expression of HIF-1α with histopathological type,pathology classification and age of patients had no relationship.The expression of HIF-1α in drug resistance group was higher than in sensitive group（P〈0.001）.Conclusion： HIF-1α expression may be related with the growth of ovarian cancer,lymph node metastasis and drug re-sistance.HIF-1α can become the new molecular therapeutic targets.