摘要
Mcl-1(myeloid cell leukemia-1)是Bcl-2家族的一个新成员,在凋亡调控中具有重要作用,此外它还可以直接对细胞分化和细胞周期进行调控,进一步研究表明Mcl-1在胚胎形成,组织发育和免疫系统中具有重要作用,Mcl-1表达异常可以导致恶性肿瘤的发生,因此通过反义寡核苷酸技术或小分子干扰RNA抑制Mcl-1基因的表达,促进细胞凋亡并提高肿瘤细胞对放疗及化疗的敏感性,为难治性肿瘤的治疗开辟了一条新途,所以对Mcl-1的深入研究具有重要意义。
Myeloid cell leukemia-1（Mcl-1）,which has important role in regulation of apoptosis besides it directly regulate cell differentiation and cell cycle,is a new member of B cell lymphoma-2（Bcl-2） families.Further study show that Mcl-1 has important role in embryogenesis,tissure development,and immune system and abnormal expression of Mcl-1 contribute to tumourgenesis.We may develop a new approach by inhibiting mcl-1 gene expression through Mcl-1 antisense oligonucleotide or small interfere RNA,facilitate tumour cell apoptosis,and improve tumor cell sensitivity to radiotherapy and chemotherapy.So it has significant meaning in further study for Mcl-1.
出处
《现代生物医学进展》
CAS
2012年第2期393-397,共5页
Progress in Modern Biomedicine
基金
湖北省教育厅基金资助(B20092404)
