硫柳汞SD大鼠单次静脉注射药代动力学研究

Pharmacokinetics of Thiomersal in SD Rats Following Intraveous Administration

目的:研究硫柳汞在SD大鼠静脉注射后的药代动力学特征。方法:SD大鼠单剂量(高、低2个剂量组)静脉注射硫柳汞,以冷原子吸收测汞法测定不同时间点的血药浓度,用DAS2.0软件获取各剂量组的主要药代动力学参数。结果:硫柳汞在高(30mg/kg)和低剂量(15 mg/kg)的消除半衰期t1/2z分别为171.61±0.33h,,156.54±18.61h;AUC0-144h分别为16748.65±7296.61mg/L*h,9131.94±1406.68 mg/L*h。结论:硫柳汞在大鼠体内的代谢过程呈线性动力学特征,半衰期约在130～170h左右。

Objective： To study the pharmacokinetics of Thiomersal in rats after intravenous injection.Methods： Thiomersal was intravenously injected to SD rats,once at 15mg/kg and 30mg/kg respectively.Blood samples were serially collected and the mercury level was determinated by cold-vapour atomic absorption spectroscopy.Pharmacokinetic parameters were integrated using DAS 2.0 software.Results： At the dose of 30 mg/kg and 15 mg/kg,the half-life of Thiomersal were 171.61±0.33h and 156.54±18.61h respectively,and AUC0-144h were 16748.65±7296.61 mg/L＊h and 9131.94±1406.68 mg/L＊h,respectively.Conclusion： Thiomersal presented a linear Pharmacokinetics in the metabolism process of rats with half-life of about 130 - 170h or so.