乳腺癌组织中血管内皮生长因子和抑癌基因Maspin的表达及意义

Expression of Vascular Endothelial Growth Factor and Maspin in Breast Carcinoma and its Clinical Significance

目的:探讨血管内皮生长因子(vascular endothelial growth factor,VEGF)和抑癌基因Maspin(mammary-serpin)在乳腺癌组织中的表达。方法:采用免疫组织化学法法检测乳腺癌组织与癌旁正常组织中的VEGF和Maspin表达水平。结果:VEGF在正常乳腺组织中表达率为44.4%(40/90),在乳腺癌组织中的表达率为91.1%(82/90),Maspin在正常乳腺组织中表达率为100%(90/90),在乳腺癌组织中的表达率为68.9%(62/90)。VEGF蛋白表达水平与乳腺癌TNM分期、淋巴结转移有关(P<0.01),Maspin蛋白的表达与乳腺癌的组织学分型、分级、淋巴结转移均有关(P<0.05)。结论:检测VEGF和Maspin有利于乳腺癌的生物学行为评估和乳腺癌预后判断。

Objective： To explore the expression of VEGF and Maspin protein in breast cancer tissues.Methods： We examined the expression of the level of VEGF and Maspin expression in breast cancer tissues and adjacent breast normal tissues by immunohistochemistry.Results：The expression rate of VEGF was 91.1%（82/90）in breast carcinoma tissues,but 44.4%（40/90）in normal tissues;as for Maspin,the case was to contrary,the expression rate of Maspin protein was 68.9%（62/90）in breast carcinoma tissues,and 100%（90/90）in normal tissues.There was correlation between the expression of these two proteins.The expression of VEGF was related to TNM stage and lymph node metastasis of breast carcinoma（P〈0.01）,there was a close relation between the expression of Maspin and histology type,histology grade and lymph node metastasis of breast carcinoma（P〈0.05）.Conclusion：These results demonstrate that examination of expression of VEGF and Maspin at the same time might be beneficial in judging biological behavior and prognosis of breast carcinoma.