胃腺癌患者舌苔变化及其血清sE-cad水平和临床检验指标的相关性

Relationships among changes in tongue coating,levels of serum soluble E-cadherin,clinical examination parameters and gastric adenocarcinoma

目的:探讨胃腺癌患者和正常人的舌苔形成与血清sE-cad水平的相关性.方法:采用临床病例-对照法,应用ELISA测定266例胃腺癌患者和252例对照人群的血清sE-cad水平,非参数检验分析血清sE-cad水平、临床检验指标和舌苔类型的相关性.结果:胃腺癌组血清sE-cad水平显著高于对照组(P<0.01),术前者血清sE-cad水平显著高于术后者(P<0.05),胃腺癌未转移者血清sE-cad水平显著高于转移者(P<0.05).胃腺癌组血清sE-cad水平表现为白厚苔>白薄苔>黄厚苔>黄薄苔>剥苔,有统计学意义(P<0.05),对照组血清sE-cad水平表现为黄薄苔>黄厚苔>白薄苔>白厚苔>剥苔,但无统计学意义(P>0.05).胃腺癌组临床检验指标异常者比例均高于对照组(P<0.05),特别是总蛋白异常的厚苔、薄苔胃腺癌患者的血清sE-cad水平均高于总蛋白异常的厚苔、薄苔对照组(P<0.05).结论:胃腺癌患者苔质厚薄变化、血清总蛋白和sE-cad水平检测对临床胃腺癌防治可能有重要的临床价值.

AIM：To investigate the relationship between serum soluble E-cadherin （sE-cad） levels and changes in tongue coating in patients with gastric adenocarcinoma and healthy controls.METHODS：This was a case-control study involving 266 gastric adenocarcinoma cases and 252 healthy controls.Serum levels of sEcad were measured by ELISA.The correlations among serum sE-cad levels,clinical examination parameters and type of tongue coating were analyzed using nonparametric tests.RESULTS：Serum levels of sE-cad were significantly higher in gastric adenocarcinoma cases than in healthy controls （P 0.01）,in patients before operation than in those after operation （P 0.05）,and in patients with metastasis than in those without metastasis （P 0.05）.The levels of sE-cad were highest in patients with white thick coating,followed by those with white thin coating,yellow thick coating,yellow thin coating and exfoliative coating （P 0.05）,whereas the order in healthy controls was yellow thin coating,yellow thick coating,white thin coating,white thick coating and exfoliative coating （P 0.05）.The proportion of gastric adenocarcinoma cases with abnormal clinical examination parameters was higher than that of healthy controls （P 0.05）.Especially,gastric adenocarcinoma cases with thick and thin coatings and abnormal total protein had higher levels of sE-cad than healthy controls （P 0.05）.CONCLUSION：The changes in thick and thin coatings and levels of total protein and sE-cad in serum can offer clues for diagnosis and treatment of gastric adenocarcinoma.