原发性肝细胞癌与X线修复交叉互补基因1遗传位点的相关研究

Association analysis of XRCC1 genetic polymorphism loci with primary heptocellular carcinoma in chinese population

目的研究X线修复交叉互补基因1(XRCC1)遗传位点399多态性对中国人群原发性肝细胞癌的相关性。方法通过检索PubMed和CNKI等数据库,收集有关XRCC1多态性与原发性肝细胞癌关联的6篇相互独立研究文献,对1072原发肝癌病例和1400健康人进行Meta分析和关联研究。结果通过XRCC1 399位点所有数据研究,经等位基因病例对照,等位基因G的OR值(95%CI)为1.23(0.96,1.59),=0.11;与基因型AA比较,基因型AG+GG的OR值(95%CI)为1.33(0.92,1.92),=0.13,说明该位点多态性对原发性肝癌发生不是危险因子。通过层次分析,在乙肝或黄曲霉素暴露所诱导的那80%的肝癌患者中,该位点是原发性肝癌发生的危险因子在未知病因所诱导的肝癌患者中,该位点未显示对原发性肝癌发生危险作用。结论中国人群XRCC1基因遗传位点399与乙肝或黄曲霉素暴露所诱导的肝癌发生相关。

Objective To investigate the association between XRCC1 genetic polymorphism Arg399Gln and primary heptocellular carcinoma（HCC） in chinese population.Methods Six independent literatures in PubMed and CNKI including 1072 HCC cases and 1400 controls were searched and enrolled in the Meta analysis and association study.Results The allele G of XRCC1 genetic loci 399 was not associated with HCC risk when compared with the allele A（OR（95%CI） was 1.23（0.96,1.59）and =0.11）,the variant genotypes（GG＋AG） of XRCC1 genetic loci 399 were not associated with HCC risk when compared with the wild-type AA homozygote（OR（95%CI） was 1.33（0.92,1.92）and = 0.13）.XRCC1 genetic loci 399 was the dangerous factor leading to HCC in the 80% HCC influenced by hepatitis B or aflatoxin B1 exposure,but the loci has no relation with HCC risk in HCC influenced by unknown reason.Conclusion The XRCC1 genetic loci 399 has relation with HCC influenced by hepatitis B or aflatoxin B1 exposure in chinese population,.