期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

小鼠脊髓损伤模型的行为学评估方法 被引量：3

Behavioral assessment methods following spinal cord injury in mice
原文传递
导出
摘要 目前已存在多种针对小鼠脊髓损伤(spinal cord injury,SCI)模型的行为学评分方法,常用的包括Basso Mouse Scale(BMS)法、单帧运动分析、爬梯实验和斜面实验等。其中,BMS和单帧运动分析属运动学分析,前者的评分与损伤程度有较高一致性,但是较为复杂,后者观察指标简单,但是只能做粗略的评估;爬梯实验和斜面实验是观察小鼠完成某一任务的能力而评分,指标客观,但前者应用前提是小鼠已恢复到可负重行走,并需要事先对小鼠进行训练,后者的敏感性可能有品系差异。 At the present stage,a variety of behavioral assessments for spinal cord injury（SCI） mice models has come into being,including Basso Mouse Scale（BMS）,single-frame motion analysis,ladder-climbing test,inclined plane,recovery indices.BMS and single-frame motion analysis belong to kinematic measures,BMS has a high correlation with injury severity though it is complex,single-frame motion analysis is simple but only can evaluate the injury sketchily.Ladder-climbing test and inclined plane belong to endpoint measures,i.e.,scoring the mice based on their ability to accomplish a particular goal,in which the items are more objective.However the former is suitable for SCI mice,capable of weight supported stepping and needs training the mice in advance,the latter＇s sensitivity may have strain difference.
作者 孙源君 马坚妹
机构地区 大连医科大学 大连医科大学人体解剖学教研室
出处 《解剖科学进展》 CAS 2012年第2期173-176,181,共5页 Progress of Anatomical Sciences
关键词 评估方法 损伤模型 脊髓损伤 行为学 小鼠 评分方法 运动分析 损伤程度
分类号 R322.81 [医药卫生—人体解剖和组织胚胎学]
  • 相关文献

参考文献22

  • 1Lu J,Ashwell,Ken WS,et al.Advances in secondary spinal cord injury:role of apoptosis[J].Spine,2000,25(14):1859-1866.
  • 2Basso DM,Beattie MS,Bresnahan JC.A sensitive and reliable locomotor rating scale for open field testing in rats[J].J Neurotraum,1995,12(1):1-21.
  • 3Kunkel-Bagden E,Dai HN,Bregman BS.Methods to assess the development and recovery of locomotor function after spinal cord injury in rats[J].Exp Neurol,1993,119(2):153-164.
  • 4Rivlin AS,Tator CH.Objective clinical assessment of motor function after experimental spinal cord injury in the rat[J].J Neurosurg,1977,47(4):577-581.
  • 5Kloos AD,Fisher LC,Detloff MR,et al.Stepwise motor and all-or-none sensory recovery is associated with nonlinear sparing after incrdmental spinal cord injury in rats[J].Exp Neurol,2005,191(2):251-265.
  • 6Kuhn PL,Wrathall JR.A mouse model of graded contusive spinal cord injury[J].J Neurotra,1998,15(2):125-140.
  • 7Wamil AW,Wamil BD,Hellerqvist CG.CM101-mediated recovery of walking ability in adult mice paralyzed by spinal cord injury[J].Proc Natl Acad Sci USA,1998,95:13188-13193.
  • 8Pan W,Kastin AJ,Bell RL,et al.Upregulation of tumor necrosis factor alpha transport across the blood-brain barrier after acute compressive spinal cord injury[J].J Neurosci,1999,19:3649-3655.
  • 9Noble LJ,Donovan F,Igarashi T,et al.Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events[J].J Neurosci,2002,22(17):7526-7535.
  • 10Sheng H,Wang H,Homi HM,et al.A no-laminectomy spinal cord compression injury model in mice[J].J Neurotraum,2004,24(5):595-603.

同被引文献38

  • 1周继辉,姚猛,王岩松,隋福革,刘玉刚,赵丛然,田飞鹏.新型脊髓纳米组织工程支架的组织相容性[J].中国组织工程研究,2013,17(21):3854-3861. 被引量：4
  • 2Bunge RP, Puckett WR, Becerra JL, et al. Observations on the pathology of human spinal cord injury: A review and classification of 22 new cases with details from a case of chronic cord compression with extensive focal demyelination[J]. Adv Neurol, 1993, 59: 75-89.
  • 3Bunge RP, Puckett WR, Hiester ED. Observations on the pathology of several types of human spinal cord injury, with emphasis on the astrocyte response to penetrating injuries[J]. Adv Neurol, 1997, 72: 305-315.
  • 4Tarot CH, Fehlings MG. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms[J]. Neurosurg, 1991, 75(7): 15-26.
  • 5Metz GA, Curt A, van de Meent H, et al. Validation of the weight- drop contusion model in rms: A comparative study of human spinal cord injury[J]. Neurotrauma, 2000, 17(1): 1-17.
  • 6Norenberg MD, Smith J, Marcillo A. The pathology of human spinal cord injury: Defining the problems[J]. Neurotrauma, 2004, 21(4): 429-140.
  • 7Allen A. Surgery of experimental lesion of spinal cord equivalent to crush injury of fracture dislocation of spinal column: A preliminary report[J]. JAMA, 1911, 37(11): 878-880.
  • 8Wrathall JR, Pettcgrew RK, Harvey F. Spinal cord contusion in the rat: Production of graded, reproducible, injury groups[J]. Exp Nenrol, 1985, 88(1): 108-122.
  • 9Gruner JA. A monitored contusion model of spinal cord injury in the rat[J]. Neurotrauma, 1992, 9(2): 123-126.
  • 10Rivlin AS, Tator CH. Objective clinical assessment of motor function after experimental spinal cord injury in the rat[J]. Neurosurg, 1977, 47(4): 577-581.

引证文献3

二级引证文献8

解剖科学进展
2012年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部