食物敏感与肠易激综合征研究进展

Irritable bowel syndrome and food allergy

肠易激综合征(irritable bowel syndrome,IBS)是一种以腹痛或腹部不适伴排便习惯改变为特征的功能性胃肠病,其症状反复,严重地影响了患者的生活质量.研究发现,食物可引发或加重IBS患者的症状,其实质即食物过敏和食物不耐受,但具体的发病机制尚未得到肯定,目前包括细菌"代谢‘毒物’假说"、"免疫或炎症反应假说"、"物理或化学刺激假说"等.因此食物因素在IBS发病中的作用越来越受到重视,成为当前研究IBS病因的热点之一,本文将对食物敏感及食物引发IBS的可能机制、检测方法及干预措施的研究进展作一综述.

Irritable bowel syndrome （IBS） is a kind of func- tional gastrointestinal disease characterized by abdominal pain or discomfort associated with changes in bowel habits. The alternating symp- toms of IBS seriously affect the patients＇ quality of life. Some studies have found that food could cause or aggravate the symptoms of IBS possibly by inducing food allergy and food intolerance. However, the specific mechanisms have not been established yet. Currently there are ＂bacterial ＇toxin＇ hypothesis＂, ＂immune or inflammatory response hypothesis＂ and ＂physical or chemical irritation hypothesis＂ explaining the role of food in the pathogenesis of IBS. It has been known that food factors play a very important role in the pathogenesis of IBS. This article reviews food allergy and the possible mechanisms, diagnosis and treatment of IBS caused by food.