中国藏族PSCA基因rs2294008多态性与胃癌遗传易感性的关系

Relationship between the rs2294008 polymorphism of the PSCA gene and susceptibility to gastric cancer in Tibetans

目的:研究前列腺干细胞抗原基因(prostatestem cell antigen gene,PSCA)rs2294008位点多态性与中国藏族胃癌患者遗传易感性的关系.方法:收集185例藏族胃癌患者与200例健康人群的外周血样本,提取基因组DNA,采用dHPLC方法进行PSCA基因rs2294008位点分型.结果:PSCA基因rs2294008位点3种基因型C C、C T、T T在胃癌病例组中频率分别为:40.00%、48.65%和11.35%,而在对照组中分别为54.00%、39.50%和6.50%.与CC型比较,携带CT,TT型基因型者胃癌发生的危险性增加,OR值分别为1.66(95%CI 1.09-2.54)和2.36(95%CI 1.11-5.00).结论:PSCA基因rs2294008位点CT,TT基因型增加中国藏族人群的胃癌易感性.

AIM： To investigate the relationship between the rs2294008 polymorphism of the PSCA gene and susceptibility to gastric cancer in Tibetans. METHODS： The rs2294008 genotypes were deter- mined by PCR-based denaturing high-perfor- mance liquid chromatography and direct DNA sequencing in 185 sporadic cases of gastric can- cer and 200 controls recruited in Tibet.normal controls, and the corresponding percent- ages for CT and TT genotypes were 48.65% and 39.50%, and 11.35% and 6.50%, respectively. Compared to CC genotype, CT and TT geno- types were associated with an increased risk of gastric cancer （OR = 1.66, 95%CI 1.09-2.54; OR = 2.36, 95%CI 1.11-5.00）. CONCLUSION： The rs2294008 polymorphism of the PSCA gene is associated with increased susceptibility to gastric cancer in Tibetans.