莫西沙星治疗复治耐药肺结核病的临床观察

Observation on Therapeutic Effect of Moxifloxacin for Treatment of Multidrug Resistant Pulmonary Tuberculosis

目的:评价莫西沙星治疗复治耐药肺结核病的疗效和安全性。方法:将72例复治耐药肺结核病患者随机分为治疗组和对照组,每组均为36例。治疗组给予常规复治药物并加口服莫西沙星片,对照组仅给予常规复治药物治疗。结果:治疗组在痰菌转阴率和病灶吸收方面均优于对照组(P<0.05),且未发生明显的毒副作用和不良反应。结论:莫西沙星治疗复治耐药肺结核病安全有效,值得在临床上推广应用。

To assess the efficacy and safety of moxitloxaein for treatment of multidrug resistant pulmonary tu bereulosis. Methods ：72 patients of multidrug resistant pulmona ry tuberculosis were randortdy divided into treatment group and control group, 36 patients in each group. The treatment group were treated with conventional drugs and moxifloxacin tablets, the control group with conventional drugs. 18 months later, their therapeutic effects were observed. Results：The sputum negative conversion rate of the treatment group and the loci were better than the control group,P 〈0. 05. No adverse effect was found in the observation. Conclusion：Efficacy and safety of moxifloxacin tablets in the treatment of muhidrug resistant pulmonary tuber- culosis, worthy of clinical application.