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气道平滑肌细胞在COPD气道重塑发病中的作用 被引量:2

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摘要 慢性阻塞性肺疾病气道平滑肌重塑是近年来研究热点。平滑肌细胞所致气道重塑可能是通过表达细胞因子、基质金属蛋白酶类、生长因子等引起小气道细胞外基质增加,最终导致气道重塑。许多潜在的反应性差的气道平滑肌细胞异常,对β受体激动剂和激素的治疗反应不佳。为了达到最佳的治疗效果,更多的导致气流受限的潜在的特异性靶位在气道炎症和气道重塑过程中作用的研究应进一步深入。
出处 《齐鲁医学杂志》 2012年第1期93-94,共2页 Medical Journal of Qilu
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  • 1RABE K F,HURD S,ANZUETO A,et al.Global strategyfor the diagnosis,management,and prevention of chronic ob-structive pulmonary disease:GOLD executive summary[J].Am J Respir Crit Care Med,2007,176:532-555.
  • 2HOGG J C,TIMENS W.The pathology of chronic obstruc-tive pulmonary disease[J].Annu Rev Pathol,2009,4:435-459.
  • 3HOGG J C,CHU F,UTOKAPARCH S,et al.The nature ofsmall-airway obstruction in chronic obstructive pulmonary di-sease[J].N Engl J Med,2004,350:2645-2653.
  • 4WRIGHT J L,POSTMA D S,KERSTJENS H A,et al.Air-way remodeling in the smoke exposed guinea pig model[J].Inhal Toxicol,2007,19:915-923.
  • 5CHURG A,WANG R,WANG X,et al.Effect of an MMP-9/MMP-12inhibitor on smoke-induced emphysema and airwayremodelling in guinea pigs[J].Thorax,2007,62:706-713.
  • 6TONIO P,REINOUD G,ANDRIES H,et al.Cigarettesmoke and lipopolysaccharide induce a proliferative airwaysmooth muscle phenotype[J].Respiratory Res,2010,11:48-59.
  • 7TERTTU,VUOKKO L KINNULA.Glutathione-S-transfe-rases in lung and sputum specimens,effects of smoking andCOPD severity[J].Respir Research,2008,9(13):80.
  • 8PARAMESWARAN.Role of extracellular matrix and its re-gulators in human airway smooth muscle biology[J].Cell Bio-chem Biophy,2006,44:139-146.
  • 9BART G J D.Extracellular matrix proteins differentially regu-late airway smooth muscle phenotype and function[J].Am JPhysiol Lung Cell Mol Physiol,2007(292):L1405-L1413.
  • 10PINTO-PLATA V,TOSO J,LEE K,PARK D,et al.Profi-ling serum biomarkers in patients with COPD:associationswith clinical parameters[J].Thorax,2007,62:595-601.

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