Dectin-1在角膜抗真菌免疫中的作用

Role of β-glucan receptor dectin-1 in anti-fungal infection of cornea

β-葡聚糖是真菌细胞壁多糖成分中一种高度保守的结构成分，树突状细胞相关性C型植物血凝素-1（dectin-1）作为β-葡聚糖的主要模式识别受体，广泛分布于单核巨噬细胞系统、树突状细胞（DC）及中性粒细胞等细胞中，通过对真菌的识别作用及细胞的信号转导，诱导机体产生一系列的细胞因子及趋化因子，启动非特异性免疫及特异性免疫，对机体的抗真菌免疫反应发挥重要作用。就dectin-1的分子结构、组织细胞分布、信号传导及其在角膜免疫、炎症反应中的作用等进行综述。

β-Glucan is a kind of highly conservative composition on fungal cell wall. As a recognition receptor of β-glucan, dendritic cell-associated C-type lectin-1 （dectin-1） widely distribute in single-nuclea macrophages system, dendritic cells （DC） and neutrophil ceils. Through the identification of fungal cell wall composition and cells signal transduction,dectin-1 induces the production of cytokine and chemokine and then starts a nonspecific and specific immunity response. Deetin-1 plays a key role in antifungal immune response. Here, the molecular structure, tissue cells, signal transmission and the immune inflammation role of dectin-1 in corneal infection were reviewed.