应用动态血糖监测系统评价2型糖尿病患者使用诺和锐30与诺和灵30R血糖漂移和低血糖发生率对比研究

Evaluation of Premixed Insulin with Dynamic Glucose Monitoring Methods

目的:用动态血糖监测方法评价预混胰岛素类似物和预混胰岛素治疗2型糖尿病(T2DM)时血糖漂移和低血糖发生率的差异。方法:分别使用门冬胰岛素30注射液和预混人胰岛素30R注射液治疗2组T2DM患者,采用动态血糖监测系统检测的方法,评价2组患者血糖漂移和低血糖发生率的差异。结果:2种胰岛素都能有效控制血糖,门冬胰岛素30注射液组血糖漂移度小于预混人胰岛素30R注射液组,差异有统计学意义(P<0.05),门冬胰岛素30组低血糖事件少于预混人胰岛素30R注射液,差异统计学意义(P<0.05)。结论:门冬胰岛素30注射液和预混人胰岛素30R注射液治疗T2DM,在血糖控制良好时,前者血糖漂移及低血糖发生率低于后者。

Objective：Dynamic glucose monitoring methods for the evaluation of premixed insulin analogues and premixed insulin treatment of type 2 diabetes mellitus （ T2DM ） when blood glucose excursion and hypoglycemia incidence rate difference. Methods：Using insulin aspart 30 injection and premixed human insulin 30R injection on the treatment of 2 group T2DM patients, using dynamic blood glucose monitoring system detection method, evaluation of 2 groups of patients with blood glucose excursion and hypoglycemia incidence rate difference. Results ：2 kinds of insulin can effectively control blood sugar, insulin aspart 30 injection blood glucose excursion lower than premixed human insulin 30 R injection group, the difference was statistically significant （ P 〈 0.05 ）, insulin aspart 30 groups of hypoglycemic events less than premixed human insulin 30 R injection, these differences were statistically significant （ P 〈 0.05 ）. Conclusion： Insulin aspart 30 injection and premixed human insulin 30 R injection in the treatment of T2DM, in well control of blood glucose, the glucose excursion and hypoglycemia incidence is lower than the latter.