阿托伐他汀对急性脑梗死患者超敏C-反应蛋白和血脂的影响

Effects of Atorvastatin on Serum High Sensitivity C-Reactive Protein and Lipids in Patients with Acute Cerebral Infarction

目的观察阿托伐他汀对急性脑梗死患者血清超敏C-反应蛋白(hs-CRP)和血脂的影响。方法对330例诊断为急性脑梗死的患者采用常规药物与阿托伐他汀口服治疗4周,分别在患者入院时和治疗4周后进行血清hs-CRP和血脂测定。结果急性脑梗死患者治疗4周后血清hs-CRP、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平均较治疗前明显降低(P<0.01),而高密度脂蛋白胆固醇(HDL-C)水平则较治疗前明显升高(P<0.01)。结论阿托伐他汀可通过降低急性脑梗死患者的hs-CRP水平和调整血脂水平而减轻脑缺血性损害。

Objective To observe the effects of atorvastatin on serum high sensitivity C-reactive protein （hs- CRP） and lipids in the patients with acute cerebral infarction （ACI）. Methods Three hundred and thirty patients with ACI were received the therapy of conventional drugs and oral atorvastatin for 4 weeks. The serum hs- CRP and lipids were detected on admission and after 4-week treatment. Results Compared with before treatment, the serum level of hs- CRP, TC, TG and LDL- C after treatment were decreased signifi- cantly （all P 〈 0. 01）, while the HDL-C level was increased significantly in ACI patients. Conclusion Atorvastatin can lighten cerebral ischemic injury by decreasing the levels of serum lipids and hs- CRP in the patients with ACI.