氨曲南和头孢西丁钠治疗下呼吸道感染的疗效对比

Comparison of Clinical Effects of Cefoxitin Sodium and Aztreonam for Treating Lower Respiratory Tract Infection

目的比较国产氨曲南和头孢西丁钠治疗下呼吸道感染的临床疗效、细菌清除率和安全性。方法将80例下呼吸道感染患者随机分成氨曲南治疗组(A组)和头孢西丁钠对照组(B组),每组40例,分别给予氨曲南1.0 g、头孢西丁钠2.0 g静脉滴注治疗。结果 A组、B组的临床有效率分别为82.50%和80.00%,细菌清除率分别为90.00%和85.00%,两组差异无统计学意义(P>0.05)。结论氨曲南和头孢西丁钠治疗下呼吸道感染均安全可靠,临床可根据细菌学检查选择合适的抗菌药物。

Objective To compare the therapeutic effects, bacterial clearance rate and safety of cefoxitin sodium and aztreonam for the treatment of the patients with lower respiratory tract infection. Methods A total of 80 cases of lower respiratory tract infection were randomly divided into the study group （A） and the control group（B）, 40 cases in each group. The group A was treated by aztreonam 1.0 g and the group B by cefoxitin sodium 2.0 g. After treatment, the clinical efficacy, the bacterial clearance and adverse drug reac- tions were compared between the two groups. Results The effective rate was 82.50% in the group A and 80. 00% in the group B. The bacterial clearance rate was 90. 00% in the group A and 85.00% in the group B, showing no statistical differences between 2 groups（ P 〉 0. 05）. Conclusion Aztreonam and cefoxitin sodium both are effective and safe for treating lower respiratory tract infection. Appropriate antibacterials should be selected according to the results of the bacterial examination.