还原型谷胱甘肽治疗急性肾损伤12例

Reduced Glutathione for Treating Acute Kidney Injury in 12 Cases

目的观察还原型谷胱甘肽治疗急性肾损伤的临床疗效。方法将24例确诊的急性肾损伤患者随机分为治疗组和对照组,各12例。对照组给予血液透析和基础治疗,治疗组在此基础上联合应用还原型谷胱甘肽,比较两组患者肾功能恢复情况。结果干预治疗后患者血清胱抑素-C(cys-C)及血清肌酐均较治疗前降低,差异具有统计学意义(P<0.05)。与对照组比较,治疗组血清cys-C水平和血清肌酐浓度均显著降低,分别为(t=2.263,P<0.05和t=2.771,P<0.05)。干预治疗后,治疗组和对照组的临床缓解率分别为75.00%和33.33%,差异具有统计学意义(χ2=4.196,P=0.041)。结论急性肾损伤是临床常见危重病,在基础治疗的前提上加用还原型谷胱甘肽可在一定程度促进肾脏功能的恢复。

Objective To observe the clinical effects of reduced glutathione in treating acute kidney injury. Methods 24 patients with acute kidney injury were randomly divided into the treatment group and the control group, 12 cases in each group. The control group was given only hemodialysis and basic treatment, while on the basis of these therapies the treatment group received reduced glu- tathione. The recovery status of renal function was compared between two groups. Results After the intervention, the serum cystatin C （cys-C） and serum creatinine（Cr） were significantly reduced than before treatment（P〈 0.05）. Compared with control group, serum cys- C level and serum creatinine concentration in the treatment group were significantly reduced, respectively （t =2. 263, P =0. 035; t=2.771, P=0. 016）. The clinical remission rate were 75.00% in the treatment group and 33.33% in the control group, showing sta- tistical difference between them （~ =4. 196, P=0. 041）. Conclusion Acute kidney injury is usual clinical critical illness. On the premise of basic treatment, adding reduced glutathione will be helpful to the kidney function recovery to certain extent in the treatment of acute kidney injury