摘要
目的:制备姜黄素凝胶贴剂,优化处方中促渗剂的组成。方法:采用体外扩散池法,选用正交试验设计,以透皮率为指标,优化姜黄素凝胶贴剂中的促渗剂组成。结果:最优促渗剂组成为3%羟丙基-β-环糊精、9%冰片和3%薄荷油,姜黄素的透皮率达32%以上。结论:羟丙基-β-环糊精对姜黄素的透皮吸收有良好的促进作用。
Objective：To study the effects of penetration enhancers and their combinations on the curcumine transdermal drug de- livery（CUR-TDDS）. Methods： The penetration rate of cureumin through rat skin in vitro was measured using Valia-Chien diffusion ceils, and orthogonal design method was set up for experimental design. Results： The optimum penetration enhancers were： 3%hydroxypropyl beta cyclodextrins（ HP-β-CD）, 9% borneol and 3% peppermint oil. Conclusion： The HP-β-CD has the most potent en- hancing effect.
出处
《中药材》
CAS
CSCD
北大核心
2012年第1期141-144,共4页
Journal of Chinese Medicinal Materials
关键词
姜黄素
促渗剂
体外
Curcumin
Penetration enhancers
In vitro
