香丹注射液对脑出血患者神经功能缺损及生活能力的影响

Effect of Xiangdan injection on neurologic impairment and viability of patients with cerebral Hemorrhage

目的观察香丹注射液对脑出血患者血中白细胞介素-6(IL-6)和超敏C-反应蛋白(hs-CRP)含量以及神经功能恢复的影响。方法 71例脑出血患者分为香丹治疗组(36例)和常规治疗组(35例)。采用电化学发光法测定两组患者治疗前及治疗后第14天血清中IL-6、hs-CRP含量,并与正常对照组(35例)进行比较。同时,对两组患者神经功能缺损评分进行比较。结果香丹治疗组和常规治疗组治疗前IL-6、hs-CRP明显升高,与正常对照组比较差异均有显著性(P<0.01);治疗前香丹治疗组和常规治疗组间IL-6、hs-CRP含量差异无显著性(P>0.05);应用香丹注射液治疗后14天,常规治疗组与香丹治疗组IL-6、hs-CRP含量均有明显下降,治疗前后对比差异有显著性(P<0.01),而香丹治疗组下降更明显,香丹治疗组与常规治疗组比较差异有显著性(P<0.01)。香丹治疗组较常规治疗组的神经功能和生活能力明显改善(P<0.01)。结论脑出血患者早期血清中IL-6、hs-CRP含量明显升高,香丹可有效降低其含量,改善患者神经功能。

Objective To observe the effect of Xiangdan injection on levels of Interleukin-6（IL-6） and high sensitive C reactive protein（hs-CRP） in the blood of patients with cerebral hemorrhage and on the recovery of their neurological function.Methods 71 patients with cerebral hemorrhage were divided into the Xiangdan treatment group（36 cases） and the conventional treatment group（35 cases）.Electrochemical luminescence was adopted to measure serum IL-6,hs-CRP levels of these two groups before treatment and 14 days after treatment.Their levels were compared to those of the normal control group（35 cases）.Meanwhile,the neurological deficit scores of these two groups were compared.Results Before treatment,IL-6 and hs-CRP levels of the Xiangdan treatment group and the conventional treatment group significantly raised.Compared with the normal control group,the differences were significant（P0.01）.IL-6 and hs-CRP levels of the Xiangdan treatment group and the conventional treatment group before treatment showed no significant difference（P0.05）.14 days after treatment,IL-6 and hs-CRP levels of the conven-tional treatment group and Xiangdan treatment group were significantly lower than those before treatment（P0.01）.And those of Xiangdan treatment group decreased more significantly.Compared to the conventional treatment group,the difference was significant（P0.01）.Neurological function and viability of patients in Xiangdan treatment group were significantly improved（P0.01）.Conclusion Early serum IL-6,hs-CRP levels of patients with cerebral hemorrhage were significantly raised.Xiangdan can effectively reduce these levels and improve neurological function.