酒精性肝病患者血中睾酮和雌二醇水平的变化研究

Analysis of the changes of serum testosterone and estradiol in patients with alcoholic liver disease

目的观察酒精性肝病(alcoholic liver disease ALD)患者血清中睾酮(testosterone,T)和雌二醇(es-tradiol,E2)水平的变化。方法对长期嗜酒者、健康人进行血清T、E2的检测。结果在269例嗜酒者中符合ALD(A组)诊断者75例,占27.9%;其余为嗜酒组(B组)。A组的血清T[(12.8±6.57)nmol/L]较B组[(23.8±9.62)nmol/L]和对照组[(29.7±10.52)nmol/L]都降低(P<0.01);B组的血清T[(23.8±9.62)nmol/L]较对照组[(29.7±10.52)nmol/L]水平低(P<0.01)。A组的血清E2[(237.4±109.46)pmol/L]较B组[(133.5±66.15)pmol/L]和对照组[(128.3±54.77)pmol/L]明显增高(P<0.01),B组的E2水平高于对照组(P>0.05)。结论嗜酒者和酒精性肝病患者血清睾酮水平均降低,而在酒精性肝病患者中血清E2水平增加高,嗜酒者和对照组血清E2水平差异无统计学意义,说明慢性酒精中毒对男性睾丸功能有一定的影响。

Objective To observe the changes of testosterone（T） and estradiol（E2） in patients with alcoholic liver disease（ALD）.Methods T and E2 in alcoholics and healthy controls were detected.Results Among 269 cases of alcoholics,75 cases were ALD（A group） accounting for 27.9%,the others were alcoholic group（B group）.T[（12.8±6.57）nmol/L] in group A was lower than that in group B[（23.8±9.62）nmol/L] and control group[（29.7±10.52）nmol/L]（P0.01）.T levels in B group lower than those in control group（P0.01）.E2[（237.4±109.46）pmol/L] in group A was obviously higher than it in B group[（133.5±66.15）pmol/L] and control group[（128.30±55.47）pmol/L]P0.01）,E2[（237.4±109.46）pmol/L] in group B was higher than that in control group（P0.05）.Conclusion T levels in alcoholics and patients with ALD decrease,the E2 levels in patients with ALD increase,but there are no significant difference in alcoholics and control group,which suggests chronic alcohol poisoning have some influences on male testis function.