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硫酸软骨素微生物生产展望 被引量：1

Prospect on Microbial Production of Chondroitin Sulfate
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摘要 硫酸软骨素(CS)为糖胺聚糖家族一员,具有广泛的应用。采用与CS生物合成前体具有相似结构的细菌荚膜多糖为底物,经化学或生物修饰可生产CS及其类似物,是一种较有希望的非动物源性CS生产方式。本文对相关研究作一综述。 Chondroitin sulfate is a member of the glycosaminoglycan family, with a wide range of applications. The bacterial capsular polysaccharide having similar structure to the biosynthetic precursor of chondroitin sulfate can be used as the substrate to produce chondroitin sulfate and its analogs by chemical or biosynthesis modification, which is a promising way of non-animals CS production. This review briefly introduces the relevant studies.
作者 陈祥娥 凌沛学
机构地区 山东大学药学院 山东省生物药物研究院博士后科研工作站
出处 《食品与药品》 CAS 2012年第2期132-135,共4页 Food and Drug
关键词 硫酸软骨素 软骨素合酶 发酵 chondroitin sulfate chondroitin synthase fermentation
分类号 TQ92 [轻工技术与工程—发酵工程]
  • 相关文献

参考文献39

  • 1Xu C X, Jin H, Chung Y S, et al. Chondroitin sulfate extracted from the Styela clava tunic suppress TNF-alpha-induced expression of inflammatory factors, VCAM-1 and iNOS by blocking Akt/NF- kappa B signal in JB6 cells[J]. Cancer Lett, 2008, 264(1):93-100.
  • 2Theochairs A D, Theochairs D A, De Luca G, et al. Compositional and structural alterations of chondroitin and dermatan sulfates during the progression of atherosclerosis and aneurismal dilatation of the human abdominal aorta[J]. Biochimie, 2002, 84(7): 667-674.
  • 3Campo G M, Avenoso A, Campo S, et al.The antioxidant and antifibrogenic effects of the glycosaminoglycans hyaluronic acid and chondroitin-4-sulphate in a subchronic rat model of carbon tetrachloride-induced liver fibrogenesis[J]. Chem Biol Interact, 2004, 148(3): 125 -138.
  • 4Campo G M, Avenoso A, Campo S, et al. The antioxidant activity of chondroitin-4 -sulphate, in carbon tetrachloride-induced acute hepatitis in mice, involves NF-kappaB and caspase activation[J]. Br J Pharmacol, 2008, 155(6):945-956.
  • 5张天民.国外硫酸软骨素类膳食补充剂现状及其对我国相应产业可持续发展的启示[J].食品与药品,2008,10(1):4-7. 被引量：9
  • 6陈祥娥,凌沛学.细菌软骨素合酶[J].食品与药品,2009,11(5):52-54. 被引量：1
  • 7Ninomiya T, Sugiura N, Tawada A, et al. Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4[J]. JBiol Chem, 2002, 77 (24): 21567-21575.
  • 8DeAngelis P L, Padgett-McCue A J. Identification and molecular cloning ofa chondroitin synthase from Pasteurella multocida types F[J]. JBiol Chem, 2000, 275(31):24124- 24129.
  • 9Ramakrishnan B, Balaji P V, Qasba P K. Crystal structure of betal, 4-galactosyl-transfer -ase complex with UDP-gal reveals an oligosaccharide acceptor binding site[J]. J Mol Biol, 2002, 318(2):491-502.
  • 10Osawa T, Sugiura N, Shimada H, et al. Crystal structure of chondroitin polymerase from Escherichia coli K4[J]. Biochem Biophys Res Commun, 2009, 378(1):10-14.

二级参考文献24

  • 1De Angelis P L. Microbial glycosaminoglycan glycosyltransferases [J]. Glycobiology, 2002, 12(1): 9R-16R.
  • 2Xu C X, Jin H, Chung Y S, et al. Chondroitin sulfate extracted from the Styela clava tunic suppress TNF-alpha-induced expression of inflammatory factors, VCAM-1 and iNOS by blocking Akt/NF- kappa B signal in JB6 cells [J]. Cancer Lett, 2008, 264(1):93-100.
  • 3Theochairs A D, Theochairs D A, De Luca G, et al. Compositional and structural alterations of chondroitin and dermatan sulfates during the progression of atherosclerosis and aneurismal dilatation of the human abdominal aorta[J]. Biochimie, 2002, 84(7): 667-674.
  • 4Campo G M, Avenoso A, Campo S, et al.The antioxidant and antifibrogenic effects of the glycosaminoglycans hyaluronic acid and chondroitin-4-sulphate in a subchronic rat model of carbon tetrachloride-induced liver fibrogenesis[J]. Chem Biol Interact, 2004, 148(3):125-138.
  • 5Campo G M, Avenoso A, Campo S, et al. The antioxidant activity of chondroitin-4-sulphate, in carbon tetrachloride-induced acute hepatitis in mice, involves NF-kappaB and caspase activation[J]. Br J Pharmacol, 2008, 155(6):945-956.
  • 6Volpi N. Milligram-scale preparation and purification of oligosaccharides of defined length possessing the structure of chondroitin from defructosylated capsular polysaccharide K4[J]. Glycobiology, 2003, 13(9):635-640.
  • 7Ninomiya T, Sugiura N, Tawada A, et al. Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4[J]. J Biol Chem, 2002, 77 (24): 21567-21575.
  • 8DeAngelis P L, Padgett-McCue A J. Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida types F[J]. J Biol Chem, 2000, 275(31):24124 -24129.
  • 9Ramakrishnan B, Balaji P V, Qasba P K. Crystal structure of betal, 4-galactosyl-transfer -ase complex with UDP-gal reveals an oligosaccharide acceptor binding site[J]. J Mol Biol, 2002, 318 (2): 491-502.
  • 10Osawa T, Sugiura N, Shimada H, et al. Crystal structure of chondroitin polymerase from Escherichia coli K4[J]. Biochem Biophys Res Commun, 2009, 378(1):10-14.

共引文献8

同被引文献15

  • 1蔡苏兰,阎浩林,雷健.硫酸软骨素裂解酶发酵培养基的获得及发酵条件的优化[J].沈阳药科大学学报,2005,22(3):226-230. 被引量：3
  • 2马永华,陈士恩,臧荣鑫.硫酸软骨素的研究概况[J].中国畜牧兽医,2007,34(12):138-140. 被引量：11
  • 3Fongmoon D, Shetty AK, Basappa, et al. Chondroitinase- mediated degradation of rare 3-O-sulfated glucuronic acid in functional oversulfated chondroitin sulfate K and E[J].The Journal of biological chemistry,2007,282(51):36895-36904.
  • 4Yamaguchi T, Zhu Xia, Masada M, et al. Purification and characterization of a novel cysteine synthase isozyme from spinach hydrated seeds[J]. Bioscience, Biotechnology, and Biochemistry,1998,62(3):501-507.
  • 5Qi Zhang, Yingxiang Du, Jiaquan Chen, et al. Investigation of chondroitin sulfate D and chondroitin sulfate E as novel chiral selectors in capillary electrophoresis[J]. Analytical and bioanalytical chemistry,2014,406(5):1557-1566.
  • 6Chao Cai, Kemal Solakyildirim, Bo Yang, et al. Semi- synthesis of chondroitin sulfate-E from chondroitin sulfate-A[J]. Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccha rides,2012,87(1):822-829.
  • 7Takuo Nakano, Lech Ozimek. Detection of keratan sulfate by immunological methods in commercial ehondroitin sulfate preparations[J]. Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important P o 1 ysaccharides,2014,99:547-552.
  • 8Charalampos G Panagos, Derek Thomson, Claire Moss, et al. Characterisation of hyaluronic acid and chondroitin/dermatan sulfate from the lumpsucker fish, C lumpus[J]. Carbohydrate Polymers: Scientifieand Technological Aspects of Industrially Important Polysaccharides,2014,106:25-33.
  • 9Izumikawa T, Uyama T, Okuura Y, et al. Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor[J]. The Biochemical Journal,2007,403(Pt.2):545-552.
  • 10Lim J J, Temenoff J S. The effect of desulfation of chondroitin sulfate on interactions with positively charged growth factors and upregulation of cartilaginous markers in encapsulated MSCs[J]. Biomaterials,2013,34(21):5007- 5018.

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食品与药品
2012年 第2期

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