尿微量白蛋白与血β2-微球蛋白测定对糖尿病肾病早期诊断的价值

Value of urinary microalbumin and blood β2-microglobulin detection in early diagnosis of diabetic nephropathy

目的探讨尿微量白蛋白(MALB)及血β2-微球蛋白(β2-MG)对糖尿病肾病的早期诊断价值。方法用放射免疫法测定早期糖尿病肾病组(DN组)、单纯糖尿病组(DM组)及正常对照组的尿MALB、血β2-MG、血尿素氮(BUN)、血肌酐(Cr)。结果尿MALB和血Cr在正常对照组与单纯DM组间差异不显著(P>0.05);血β2-MG和血BUN在单纯DM组与正常对照组间差异显著(P<0.05或P<0.01);在早期DN组,4项指标均比正常对照组和单纯DM组显著升高(P<0.01)。结论尿MALB和血β2-MG是诊断早期糖尿病肾病的敏感而可靠的指标。

Objective To study the value of urinary microalbumin（MALB）and blood β2-microglobulin（β2-MG）detection in early diagnosis of diabetic nephropathy（DN）.Methods The urinary MALB,blood β2-MG,blood urea nitrogen（BUN）and serum creatinine（Cr）in early DN group,simple diabetes mellitus group（DM group）and control group were detected by the method of radio-immunity.Results There was no significant difference in urinary MALB and blood Cr between the DM group and the control group（P〉0.05）.There were significant differences in blood β2-MG and blood BUN between the above two groups（P〈0.05 or P〈0.01）.In the early DN group,all the four indexes significantly increased compared with those in the other two groups（P〈 0.01）.Conclusion Urinary MALB and blood β2-MG are sensitive and reliable indexes in the diagnosis of early diabetic nephropathy