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EMMPRIN在不稳定斑块中的作用及分子机制 被引量：1

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摘要 metalloproteinaseinducer，EMMPRIN）是一种高度糖基化，分子量约50～60kDa的跨膜糖蛋白，又叫basigin、M6、Neurothelin和CDl47分子，是免疫球蛋白超家族成员之一。EMMPRIN在体内可参与多种生理病理过程，如肿瘤的侵袭和转移、新生血管的形成等,
作者 梁星 杨丽霞
机构地区 成都军区昆明总医院心内科
出处 《西南国防医药》 CAS 2012年第3期333-335,共3页 Medical Journal of National Defending Forces in Southwest China
关键词 细胞外基质金属蛋白酶诱导因子 动脉粥样硬化 不稳定斑块 基质金属蛋白酶
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献23

  • 1Major T C,Liang L,Lu X,et al.Extracellular matrix metalloproteinase inducer(EMMPRIN)is induced upon monocyte differentiation and is expressed in human atheroma[J].Arterioscler Thromb Vasc Biol,2002,22(7):1200-1207.
  • 2Riethdorf S,Reimers N,Assmann V,et al.High incidence of EMMPRIN expression in human tumors[J].Int J Cancer,2006,119(8):1800-1810.
  • 3Abe N,Osanai T,Fujiwara T,et al.C-reactive protein-induced upregulation of extracellular matrix metalloproteinase inducer in macrophages:inhibitory effect of fluvastatin[J].Life Sci,2006,78(9):1021-1028.
  • 4Tang W,Chang S B,Hemler M E.Links between CD147 function glycosylation,and caveolin-1[J].Mol Biol Cell,2004,15(9):4043-4050.
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二级参考文献26

  • 1王川怡,张怀勤,章义利,周浩,李上共,徐力辛.PKC和MMPs在实验性大鼠动脉粥样硬化形成中的作用及丹参的作用机制[J].中国病理生理杂志,2005,21(1):116-120. 被引量：11
  • 2何清,王长谦,葛恒,郭炳诗,何奔.特异性抑制单核细胞中EMMPRIN基因表达的siRNA筛选和鉴定[J].上海交通大学学报（医学版）,2007,27(6):681-684. 被引量：5
  • 3Yoon YW, Kwon HM, Hwang KC, et al. Upstream regulation of matrix metalloproteinase by EMMPRIN: extracellular matrix metalloproteinase inducer in advanced atherosclerotic plaque [J]. Atherosclerosis, 2005, 180(1): 37-44.
  • 4Hong MK, Mintz GS, Lee CW, et al. Comparison of coronary plaque rupture between stable angina and acute myocardial infarction: a three vessel intravaseular ultrasound study in 235 patients [J]. Circulation, 2004, 110(8) : 928 -933.
  • 5Burker AP, Traey BP, Kolodgie F, et al. Elevated C-reactive protein values and atherosclerosis in sudden coronary death: association with different pathologies [ J ]. Circulation, 2002, 105 ( 17 ) : 2019 - 2023.
  • 6Blankenberg S, Rupprecht HJ, Poirier O, et al. Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease [ J ]. Circulation, 2003, 107(12): 1579 -1585.
  • 7Sluijter JP, Pulskens WP, Schoneveld AH, et al. Matrix metalloproteinase 2 is associated with stable and matrix metalloproteinases 8 and 9 with vulnerable carotid atherosclerotic lesions [ J ]. Stroke, 2006, 37(1) : 235 -239.
  • 8Major TC, Liang L, Lu X, et al. Extracellular matrix metalloproteinase inducer (EMMPRIN) is induced upon monocyte differentiation and is expressed in human atheroma[ J]. Arterioscler Thromb Vasc Biol, 2002, 22(7): 1200- 1207.
  • 9Zhang JF, Ge H, Wang CQ, et al. Inhibitory effect of PPAR on the expression of EMMPRIN in macrophages and foam cells [ J ]. Int J Cardiol, 2007, 117(3) : 373 -380.
  • 10Abe N, Osanai T, Fujiwara T, et al. C-reactive protein-induced upregulation of extracellular matrix metalloproteinase inducer in macrophages : inhibitory effect of fluvastatin[J]. Life Sci, 2006, 78 (9) : 1021 - 1028.

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西南国防医药
2012年 第3期

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