20例人感染新型布尼亚病毒病的临床和流行病学特征分析

Clinical and epidemiological characteristics on 20 cases of SFTSV infection

目的分析人感染新型布尼亚病毒病的临床特点和流行病学特征,为制定预防控制措施提供依据。方法采用统一的诊断标准和流行病学个案调查表对病例进行调查。结果 2010年江苏省境内报告的33例疑似病例中有20例确诊人感染新型布尼亚病毒病,病死率为30%。临床表现主要为发热(100%)、乏力(80%)、畏寒和呕吐(60%);血常规检查有血小板计数减少(100%)和白细胞计数减少(90%);病例多来自丘陵地区,以男性、中老年、农民为主,发病时间呈两个高峰,分别为6～7月和9～10月,部分病例发病前有明确的蜱叮咬史。结论 SFTS病例发病初期临床症状不典型,发病有地域特征,散发病例多见,但不排除人与人传播的可能。

In order to explore the clinical and epidemiological characteristics of cases with severe fever with thrombocytopenia syndrome bunyavirus（SFTSV） infection,the uniform diagnosis standard and questionnaire were used to collect the information of cases diagnosed in Jiangsu Province,2010.Twenty cases were confirmed as SFTSV infection by real-time RT-PCR with a fatality rate of 30%,whose primary clinical manifestations included fever（100%）,weakness（80%）,chills（60%）,vomiting（60%）,thrombocytopenia（100%） and leucopenia（90%）.All 20 cases（100%） were middle to old aged,14（70%） were men,and 16（80%） were farmers living in wooded and hilly areas and had a history of working in the fields before the illness onset.Furthermore,most confirmed cases were sporadic with two peaks and some of cases had a history of tick-biting.Although most cases occurred sporadically in hilly areas,person-to-person transmission are also likely possible.