VEGF、COX-2在甲状腺癌中的表达及临床意义

Expression of VEGF,COX-2 in Thyroid Carcinoma and Its Clinical Significance

目的探讨VEGF、COX-2在甲状腺癌肿的表达及其临床意义。方法采用免疫组化的方法,对71例甲状腺癌、53例甲状腺良性肿瘤、10例正常甲状腺组织VEGF、COX-2的表达进行检测,并将甲状腺癌的组织学分型、淋巴转移、病人年龄、性别进行对比分析。结果甲状腺癌、甲状腺良性肿瘤、正常甲状腺组织中VEGF的表达阳性率分别为77.5%,15.1%,11.1%,差异具有统计学意义(P<0.05),COX-2的表达阳性率分别为64.8%、13.2%、11.1%,差异具有统计学意义(P<0.05)。甲状腺癌中VEGF和COX-2的表达与组织病理分型和淋巴结转移比较的差异具有统计学意义(P<0.05);在乳头状癌、滤泡状癌、髓样癌、未分化癌中VEGF的表达阳性率分别为81.8%、68.8%、55.6%、92.3%,COX-2的表达阳性率分别为81.8%、88.2%、77.7%、92.3%。而与甲状腺癌患者的年龄、性别无关(P>0.05)。甲状腺癌中VEGF的表达和COX-2的表达呈正相关。结论 VEGF和COX-2在甲状腺癌的发生、发展中均起到重要作用,并且存在一定的协同作用,两者联合检测能为甲状腺癌的恶性程度以及预后判断上提供有力证据。

Objective To explore the expression of VEGF,COX -2 in thyroid carcinoma and its clinical significance. Methods Expression of VEGF, COX - 2 was detected in 71 cases with thyroid carcinoma,53 cases with thyroid adenomas, 10 cases of normal thyroid tissues by immunohistochemical method. The relationship between VEGF, COX -2 and thyroid carcinoma pathological type,lymph node metastasis status,age and gender was analyzed. Results Expression of VEGF in thyroid carcinoma,thyroid adenomas,normal thyroid tis- sues was 77.5% , 15.1% and 1 I. 1% respectively, which had significant difference （ P 〈 O. 05）. Expression of COX - 2 in thyroid carci- noma,thyroid adenomas, normal thyroid tissues was 64.8% , 13.2% and 11. 1% respectively, which had significant difference （P 〈 0.05 ）. The expression of VEGF ,COX - 2 was significant different with pathological type and lymph node metastasis status in thyroid car- cinoma（P 〈 0.05） , but there was no statistical difference among age and gender（ P 〉 0.05）. The VEGF expression in papillary thyroid carcinoma,follicular carcinomas,medullary carcinoma,undifferentiated carcinoma was 81.8% ,68.8% ,55.6% ,92.3% and COX - 2 ex- pression was 81.8% ,88.2% ,77.7% ,92.3%, respestively. Expression of VEGF was positively related to the expression of COX- 2. Conclusion VEGF,COX -2 play an important role in carcinogenesis and development of thyroid carcinoma. Combinded detection can provide valuable evidence for estimation of aggressive degree and progonosis.