慢性乙型肝炎相关胃黏膜病变特点的临床分析

Clilincal analysis on stomach mucosa disease of patients with chronic hepatitis B

目的探讨慢性乙型肝炎患者胃黏膜病理变化的特点。方法通过电子胃镜观察80例慢性乙型肝炎患者胃黏膜的镜下改变,取组织病理活检观察胃黏膜及肝脏组织的病理变化,并分析慢性乙型肝炎程度与胃黏膜病变程度的关系。结果慢性乙型肝炎患者胃黏膜内镜下改变的发生率达97.5%,组织病理(HE染色)的镜下改变达100%。胃黏膜改变呈现多样性,以慢性萎缩性胃炎为主(75.5%～77.5);胃黏膜病变程度与慢性乙型肝炎程度呈正相关(r=0.85,P<0.05)。结论慢性乙型肝炎患者普遍存在胃黏膜病变,且以萎缩性胃炎病理改变为主;胃黏膜病变程度与肝炎病情呈显著正相关,应引起患者及临床医生的重视。

Objective To observe the changes of stomach mucosa of patients with chronic hepatitis B. Methods Stomach mucosa was observed under electric gastroscope in 80 cases of patients with chronic hepatitis B. The pathology of stomach mucosa and liver tissue investigated by biopsy and pathological changes between stomach mucosa and liver tissue was analysed. Results Among 80 cases, stomach mucosa and pathological changes were found in 78 cases （97.5%） and all cases （ 100% ）, respectively. Stomach mucosa in most cases （75.0%-77.5% ） occured atrophy and the change of stomach mucosa and liver tissue of the patients correlated （r = 0. 85, P 〈 0.05）. Conclusions The stomach mucosa disease was found in all patients with chronic hepatitis B, most of whom showed atropie antral gastritis and significant relationship between stomach mucosa disease and chronic hepatitis B were found.