严重药物不良反应相关药物标记基因多态性研究状况

Advances in search for genetic polymorphism of pharmacogenetic biomarkers about severe adverse drug reactions

用药过程中发生的严重药物不良反应事件,有明显的个体差异和不可预测性,个体的基因及其多态性决定着其易感性差异。如果发现更多的药物不良反应危险基因,将有助于预测个体药物不良反应的发生。本文将部分与严重药物不良反应中的皮肤及肝脏损害有关的基因及多态性研究进展进行简要综述。

Severe adverse drug reactions,which appear to be idiosyncratic and unpredictable,are a major issue for drug therapy.Genetic factors or genome polymorphisms contribute to the susceptibility or heterogeneity.More discovery of risk alleles for these severe drug reactions may benefit the prediction of individuals.In this review,we clarify the current status of the genetic polymorphism of pharmacogenetic biomarkers about severe adverse drug reactions in skin and liver from open data sources.