高龄男性老年人尿碘与甲状腺功能的相关性研究

Correlation of urinary iodine and thyroid function in elderly men

目的探讨高龄男性老年人尿碘水平与甲状腺功能的关系，为制订老年人的保健措施提供依据。方法2010年，收集哈尔滨医科大学附属第四医院老年病房体检的75例临床健康的男性老年人，分别进行尿碘、甲状腺功能检测和B超检查。将被调查的对象分为碘适宜组和碘足量组，比较两组的甲状腺功能指标和B超检测结果。结果本次调查的75例老年男性，年龄为（79．07±4．78）岁，尿碘中位数为198．4μg／L。有62．67％（47／75）老年人碘营养状况适宜，但仍有部分个体（6．67％，5／75）处于碘过量状态。碘适宜组TSH水平[（1．91±0．82）mU／L]低于碘足量组[（4．98±0．60）mU／L，t=12．58，P〈0．05]，碘适宜组FT4水平[（4．71±0．56）pmol／L]高于碘足量组[（3．31±0．43）pmol／L，t=12．18，P〈0．05]，但两组FT4水平[（14．91±3．12）、（14．06±2．79）pmolfL]比较，差异无统计学意义（t=1．4，P〉0．05）。碘足量组甲状腺体积[（20．9±6．1）cm^3]高于碘适宜组[（17．9±5．6）cm3，t=2．11，P〈0．05]。结论足量碘摄人可能对高龄老人的甲状腺有影响。高龄人群的摄碘量是否应有所降低．应进一步研究。

Objective To study the correlation of urinary iodine and thyroid function in elderly men in Harbin, and to provide the basis for formulation of health measures for the elderly. Methods Seventy five cases of clinically healthy elderly men were enrolled for check-up of urinary iodine, thyroid function and B-ultrasound in Geriatric Ward the Forth Affiliated Hospital of Harbin Medical University in 2010. The subjects of investigation were divided into iodine appropriate and iodine sufficient groups and thyroid function parameters and B-ultrasound results were compared. Results The average age of the 75 cases of healthy elderly men was （79.07± 4.78） years old and the median of urinary iodine was 198.4 μg/L. There were 62.67% （47/75） elderly males whose iodine nutritional status was appropriate, but there were still some individuals（6.67%, 5/75） in the iodine excess state. The level of TSH of the iodine appropriate group [ （1.91± 0.82 ）mU/L ] was lower than that iodine sufficient group [ （4.98 ±0.60）mU/L, t = 12.58, P 〈 0.05], while the level of FT3 of the iodine appropriate group[ （4.71±0.56）pmol/L] was higher than that iodine sufficient group [ （3.31 ± 0.43 ）pmol/L, t = 12.18, P 〈 0.05 ]. But the difference of FT4 between the two groups[ （14.91 ± 3.12）, （14.06 ±2.79）pmol/L] was not statistically significant （t = 1.40, P 〉 0.053. The thyroid volume of iodine sufficient group[ （20.9 ± 6.1 ）cm3] was higher than that iodine appropriate group [ （17.9 ± 5.6）cm3, t = 2.11, P 〈 0.05 ]. Conclusions Sufficient quantities of iodine intake may affect the thyroid of elderly people. Whether the quantity of iodine intake of the elderly population should be decreased or not need to be further studied.