摘要
Background A recent genome-wide association study in Caucasians revealed that three loci （rs174547 in fatty acid desaturase 1 （FADS1）, rs2338104 near mevalonate kinase/methylmalonic aciduria, cobalamin deficiency, cblB type （MVK/MMAB） and rs10468017 near hepatic lipase （LIPC）） influence the plasma concentrations of high-density lipoprotein-cholesterol （HDL-C） and triglycerides （TG）. However, there are few reports on the associations between these polymorphisms and plasma lipid concentrations in Chinese individuals. This study aimed to evaluate the associations between these three polymorphisms with HDL-C and TG concentrations, as well as coronary heart disease （CHD） susceptibility in Chinese individuals.
Background A recent genome-wide association study in Caucasians revealed that three loci （rs174547 in fatty acid desaturase 1 （FADS1）, rs2338104 near mevalonate kinase/methylmalonic aciduria, cobalamin deficiency, cblB type （MVK/MMAB） and rs10468017 near hepatic lipase （LIPC）） influence the plasma concentrations of high-density lipoprotein-cholesterol （HDL-C） and triglycerides （TG）. However, there are few reports on the associations between these polymorphisms and plasma lipid concentrations in Chinese individuals. This study aimed to evaluate the associations between these three polymorphisms with HDL-C and TG concentrations, as well as coronary heart disease （CHD） susceptibility in Chinese individuals.
基金
This study was supported by grants from the National Natural Science Foundation of China （No. 81102180 and No. 30800947）, the Science ＆ Technology Supporting Projects （Social Development） of Jiangsu Province, China （No. BE2009681）, and the National Basic Research Program of Jiangsu Province, China （No. BK 2011776）.
