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Up-regulation of visfatin expression in subjects with hyperthyroidism and hypothyroidism is partially relevant to a nonlinear regulation mechanism between visfatin and tri-iodothyronine with various concentrations 被引量：11

Up-regulation of visfatin expression in subjects with hyperthyroidism and hypothyroidism is partially relevant to a nonlinear regulation mechanism between visfatin and tri-iodothyronine with various concentrations
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摘要 Background Visfatin, a visceral fat-derived adipocytokine, plays a significant physiological function in lipid metabolism. However, the precise function of visfatin and its regulation by thyroid hormones are still unknown. This study observed the plasma visfatin concentrations in subjects with hyperthyroidism and hypothyroidism in vivo, and investigated the possible reaulation mechanism between visfatin and tri-iodothvronine （T3） in vitro as a further interpretation. Background Visfatin, a visceral fat-derived adipocytokine, plays a significant physiological function in lipid metabolism. However, the precise function of visfatin and its regulation by thyroid hormones are still unknown. This study observed the plasma visfatin concentrations in subjects with hyperthyroidism and hypothyroidism in vivo, and investigated the possible reaulation mechanism between visfatin and tri-iodothvronine （T3） in vitro as a further interpretation.
作者 HAN Jing ZHANG Tian-ou XIAO Wen-hua CHANG Cui-qing AI Hua
机构地区 Department of Nutrition and Biochemistry Department ofEndocrinology
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2012年第5期874-881,共8页 中华医学杂志（英文版）
基金 This study was partially supported by grants from the National Natural Science Foundation of China （No. 30270636 and 30671015）.
关键词 thyroid dysfunction ADIPOCYTOKINES thyroid hormone 3T3-L1 cells thyroid dysfunction adipocytokines thyroid hormone 3T3-L1 cells
分类号 Q572 [生物学—生物化学] TQ464.9 [化学工程—制药化工]
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参考文献37

  • 1Moustaid N,Sul HS.Regulation of expression of the fatty acid synthase gene in 3T3-L1 cells by differentiation and triiodothyronine.J Biol Chem 1991; 266:18550-18554.
  • 2Iglesias P,Alvarez FP,Codoceo R,Diez JJ.Serum concentrations of adipocytokines in patients with hyperthyroidism and hypothyroidism before and after control of thyroid function.Clin Endocrinol (Oxf) 2003; 59:621-629.
  • 3Kansara MS,Mehra AK,Von Hagen J,Kabotyansky E,Smith PJ.Physiological concentrations of insulin and T3 stimulate 3T3-L1 adipocyte acyl-CoA synthetase gene transcription.Am J Physiol 1996; 270:E873-E881.
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  • 5Tanaka M,Nozaki M,Fukuhara A,Segawa K,Aoki N,Matsuda M,et al.Visfatin is released from 3T3-L1 adipocytes via a non-classical pathway.Biochem Biophys Res Commun 2007; 359:194-201.
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  • 8Chen MP,Chung FM,Chang DM,Tsai JC,Huang HF,Shin S J,et al.Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus.J Clin Endocrinol Metab 2006; 91:295-299.
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Chinese Medical Journal
2012年 第5期

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