期刊文献+

放疗联合伊班膦酸钠对骨转移癌的止痛疗效 被引量:1

下载PDF
导出
摘要 目的观察放疗联合伊班膦酸钠治疗对骨转移癌的止痛疗效。方法将130例骨转移癌患者随机分成单放组66例和联合组64例。两组均行6 MV-X线照射治疗,2~3 Gy/次,靶区剂量35~50 Gy;联合组在放疗前1、27 d静滴伊班膦酸钠4 mg,以后每4周重复,共2~5次。结果联合组总有效率为98.48%,单放组为87.50%,两组比较P<0.05;与单放组比较,联合组疼痛缓解起效时间明显缩短,疼痛缓解持续时间明显延长(P<0.01或<0.05)。结论放疗联合伊班膦酸钠能有效、更快地缓解骨转移癌患者的疼痛症状,延长其疼痛缓解持续时间。
出处 《山东医药》 CAS 2012年第1期62-63,共2页 Shandong Medical Journal
  • 相关文献

参考文献4

  • 1Lipton A.Management of bone metastases in breast cancer[J].Curr Treat Options Oncol,2005,6(2):161-171.
  • 2中国抗癌协会癌症康复与姑息治疗专业委员会.恶性肿瘤骨转移及骨相关疾病临床诊疗专家共识[M].北京:北京大学医学出版社,2008:18-19.
  • 3Skerjanec A,Berenson J,Hsu C,et al.The pharmacokinetics andpharmacodynamics of zoledronic acid in cancer patients with varyingdegrees of renal function[J].J Clin Pharmacol,2003,43(2):154-162.
  • 4姚元虎,章龙珍,杜秀平,唐天友,韩正祥,王建设.放射治疗联合唑来膦酸治疗骨转移癌疗效观察[J].现代肿瘤医学,2006,14(12):1595-1597. 被引量:5

二级参考文献10

  • 1李钧,张楠,孔凡英,孙玉萍.唑来膦酸治疗恶性肿瘤骨转移研究进展[J].癌症进展,2005,3(5):486-489. 被引量:11
  • 2Rosen LS,Gordon D,Tchekmedyian S,et al.Zolendronic acid versus placebo in the treatment of skeletal metastasis in patients with lung cancer and other solid tumors:a phase Ⅲ,doubleblind,randomized trial.The Zolendronic Acid Lung Cancer and Other Solid Tumors Study Group[J].J Clin Onco1,2003,21:3150~3157.
  • 3Rosen LS,David G,Simon T,et al.Long-term efficacy and safety of zoledronic acid in the treatment of skeletal metastases in patients with nonsmall cell lung carcinoma and other solid tumors:A randomized,Phase Ⅲ double-blind,placebo-controlled trial[J].Cancer,2004,100 (12):2613~2621.
  • 4Skerjanec A,Berenson J,Hsu C,et al.The pharmacokinetics and pharmacodynamics of zoledronic acid in cancer patients with varying degrees of renal function[J].J Clin Pharmacol,2003,43(2):154~162.
  • 5张文东 王秀问.唑来膦酸注射液治疗肿瘤溶骨性转移引起骨痛的二期临床研究[J].肿瘤防治杂志,2004,6(11):148-149.
  • 6Woodhouse EC,Chuaqui RF,Liotta LA.General mechanisms of metastasis[J].Cancer,1997,80 (8 Suppl):1529~1537.
  • 7Rosen CJ,Kessenich CR.Comparative clinical pharmacology and therapeutic use of bisphosphonates in metabolic bone diseases[J].Drugs,1996,51:537~551.
  • 8Rosen LS,Gordon D,Antonio BS,et al.Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma:A phase Ⅲ double-blind,comparative trial[J].Cancer J,2001,7(5):377~387.
  • 9Green JR,Muller K,Jaeggi KA.Preclinical pharmacology of CGP 42'446,a new,potent,heterocyclic bisphosphonate compound[J].J Bone Miner Res,1994,9(5):745 ~751.
  • 10Coukell AJ,Markham A.Pamidronate:a review of its use in osteolytic bone metastases,tumour-induced hypercalcaemia and Paget's disease of bone[J].Drugs & Aging,1998,12 (2):149 ~168.

共引文献5

同被引文献7

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部