摘要
目的系统评价患者输注白细胞滤过的血小板(PLT)与普通PLT预防发热性非溶血性输血反应(FNHTR)的效果。方法计算机检索PubMed,Embase,Cochrane图书馆和中国生物医学文献数据库,检索年限从建库至2010年12月。纳入白细胞滤过PLT与普通PLT比较预防FNHTR的随机对照试验。采用RevMan5.0软件进行Meta分析。结果共纳入12篇文献。Meta分析结果显示:输注白细胞滤过的PLT发生FNHTR的风险仅为普通PLT的56%ERR=0.56,95%CI(0.39,0.82),P=0.0031。PLT保存前和保存后滤过白细胞对于FNHTR发生率的影响比较,差异无统计学意义[RR=0.41,95%CI(0.15,1.14),P=0.091。结论与输注普通PLT相比,输注白细胞过滤的PLT可降低FNHTR的发生率,但白细胞滤过时机对FNHTR的发生率无显著影响。
Objective To systematically assess the effect of leukocyte-filtered platelet(PLT) and PLT concentrates transfusion on preventing febrile non-haemolytic transfusion reaction (FNHTR). Methods Such databases as PubMed, EMBASE, the Cochrane Library and CBM were searched from their establishment to December 2010. Randomized controlled trials were included. The Meta-analysis was conducted by Cochrane Collaboration's RevMan 5.0 software. Results 12 studies were selected to further Meta-analyses. The data showed that leukocyte-filtered PLT transfusion significantly decreased FNHTR [RR=0. 56,95%CI (0. 39, 0. 82), P%0. 00011 compared to PLT concentrates. Pre-storage leukocytefiltered PLT transfusion had no significant difference of FNHTR compared to post-storage leukocyte-filtered PLT transfusion [RR = 0. 41,95 M CI (0. 15, 1. 14), P = 0. 091. Conclusions Leukocyte-filtered PLT transfusion could prevent FNHTR more effectively than PLT concentrates independent on filtering time.
出处
《国际输血及血液学杂志》
CAS
2012年第2期97-100,共4页
International Journal of Blood Transfusion and Hematology
基金
四川省医学重点实验室建设项目
成都市卫生局2009年青年基金科研课题(编号0916,0917)