肿瘤物理微环境介导肿瘤耐药性研究进展

Progress in the research on tumor drug-resistance mediated by cancer physical microenvironment

肿瘤耐药性一般认为是因基因突变、扩增或表观遗传改变影响肿瘤细胞药物摄取、代谢或外排造成。肿瘤物理微环境不但影响药物在肿瘤组织中的分布，而且肿瘤微环境自身异质．陛还将造成肿瘤细胞增殖速度差异和低氧及酸中毒，并影响肿瘤的耐药性。就肿瘤物理微环境特点出发，综述了其与肿瘤耐药性之间的关系，并探讨和展望了通过改善肿瘤物理微环境来提高肿瘤化疗灵敏性的策略及未来的研究方向。

Anticancer drugs resistance is often ascribed to gene mutation, amplification or epigenetic changes that affect the uptake, metabolism or export of drugs at the cell level. Tumor physical microenvironment not only influences the drug distribution but also causes difference in cell proliferation rate and hypoxia or acidosis due to its heterogeneity, which could affect the tumor drug resistance. This review discusses the relationship between cancer physical microenvironment and drug resistance and the strategies for enhancement of the chemotherapy sensitivity through modification of the tumor physical microenvironments, as well as foreground of the research.