PT与PF方案在局部晚期宫颈癌动脉置管先期化疗中的疗效对比

PT and the PF Regimen in Locally Advanced Cervical Artery Catheter Compared the Efficacy of Chemotherapy in Early

目的:比较以顺铂为基础的两种化疗方案在局部晚期宫颈癌术前动脉置管化疗中的临床疗效。方法:将我院2007年10月-2010年10月收治的58例拟进行宫颈癌动脉置管化疗的患者随机分为PT(顺铂+紫三醇)方案组33例和PF(顺铂+5-氟尿嘧啶)方案组25例,动脉化疗1个疗程后手术。观察两种方案的近期疗效、毒副反应及手术时及术后病理等情况。结果:PT方案组临床近期有效率为90.9%,PF方案组临床近期有效率为88.0%,手术后病理提示宫旁浸润、脉管栓塞、淋巴结转移等情况两组方案均一致,差异无统计意义。但毒副反应方面,PF方案组要高于PT方案组(P<0.05)。结论:两组不同的新辅助化疗方案对治疗局部晚期宫颈癌均有效,并无明显差异。但在不良反应和副作用上PT方案优于PF方案。

Objective：To compare the two cisplatin-based chemotherapy before surgery in locally advanced cervical artery catheter in the clinical efficacy of chemotherapy.Methods：The hospital in October 2007 to October 2010 to be treated 58 cases of cervical artery catheter for chemotherapy patients were randomly divided into PT（cisplatin purple triol）program 33 cases and PF（cisplatin 5-fluorouracil）regimen in 25 cases,an intra-arterial chemotherapy treatment after surgery.Watch two programs-term effect,toxicity and surgery and postoperative pathological conditions.Results：PT Clinical short-term effect the program was 90.9%,PF recent clinical program group was 88.0% effective,prompt surgical pathologic parametrial invasion,vascular thrombosis,lymph node metastasis of two programs are the same,the difference was not statistically significant.However,toxicity aspects,PF program group higher than the PT program group（P0.05）.Conclusion：Two different neoadjuvant chemotherapy in the treatment of locally advanced cervical cancer are effective,there is no significant difference.However,adverse reactions and side effects on the PT program is better than PF regimen.