干扰素α-2b清除宫颈人乳头瘤病毒感染对维吾尔族妇女的影响

The effect of interferon therapy of human papilloma virus infection in Xinjiang Uygur women

目的观察干扰素α-2b栓对宫颈人乳头瘤病毒（HPV）感染清除的疗效。方法经基因芯片技术检测为HPV感染的新疆维吾尔族宫颈炎患者125例，根据自愿原则分为研究组（80例）及对照组（45例）。研究组患者使用干扰素仅一2b栓治疗，对照组患者则定期监测HPV的变化，均每3个月复查一次HPV。结果研究组与对照组高危型HPV感染例数分别为87和49例。12个月后，研究组与对照组高危型HPV感染清除率分别为97．7％（85／87）和91．8％（45／49），组间差异无统计学意义（P〉0．05）。第3、6、9个月研究组的清除率均高于对照组，组间差异均有统计学意义[3个月：60．9％（53／87）比40．8％（20／49）；6个月：90．8％（79／87）比59．2％（29／49）；9个月：95．4％（83／87）比71．4％（35／49），P〈0．05]。结论干扰素α-2b栓在一定程度上提高了宫颈高危型HPV感染的清除率，对防止宫颈病变有一定作用。

Objective To research the effect of α-2b-interferon suppository on cervical human papilloma virus（HPV） infection. Methods A total of 125 cases of Xinjiang Uygur cervicitis patients with high-risk HPV infection were divided into study group（ 80 cases）and control group（45 cases ）. HPV types were detected through gene chip technology. Patients in study group were treated by interferon α-2b. Results After 12 months, the clearance rate of high-risk HPV in patients of study group and control group was 97.7% （85/87）and 91.8% （45/49）respectively （ P 〉 0. 05 ）. 1,3,6,9-month clearance rates of study group and control group were compared and the differences were statistically significant [ 60. 9% （ 53/87 ） vs 40. 8% （ 20/49 ）, 90. 8% （ 79/87 ） vs 59.2% （ 29/49 ）, 95.4% （ 83/87 ） vs 71.4% （ 35/49 ）, all P 〈 0.05 ]. Conclusion Interferon alpha suppository can improve cervical high-risk HPV infection clearance rate and prevent cervical disease.