摘要
miRNA在胚胎干细胞(ES)细胞的自我更新及多能性中扮演重要角色,国内外研究结果表明,在体细胞形成诱导性多能干细胞(IPS)的过程中,许多miRNA与Sox2、Oct4和Nanog等调控因子组成调控网络。miRNA在细胞周期、重编程及表型建立过程中也起着重要的调控作用。另外,在IPS细胞形成中,miRNA很有可能代替关键转录因子。
The varied roles played by miRNA in the maintenance of embryonic stem（ES） cell self-renewal and pluripotency.Several recent studies that have begun to probe the roles of miRNAs during the reprogramming of somatic cells into induced pluripotent stem（IPS） cells.Subsequently,the function of numerous miRNAs has been shown to control the fate of ES cells and to directly influence critical gene regulatory networks controlled by pluripotency factors Sox2,Oct4,and Nanog.miRNAs are likely to influence the process of reprogramming.In addition,we posit that more than a dozen additional miRNAs are excellent candidates for influencing the generation of IPS cells.
出处
《中国畜牧兽医》
CAS
北大核心
2012年第3期85-88,共4页
China Animal Husbandry & Veterinary Medicine
基金
国家科技支撑项目(2006BAD13B08
2008BADB2B01)
