刚地弓形虫微线体蛋白3的研究进展

Research Advance on Microneme Protein 3 of Toxoplasma gondii

微线体蛋白3(MIC3)是刚地弓形虫生活史各个时期均能表达的分泌蛋白,具有较强的免疫反应性,在弓形虫对宿主细胞的识别、黏附及入侵过程中发挥重要作用。深入研究弓形虫MIC3有助于研制弓形虫病诊断制剂及疫苗以防制弓形虫病。文章综述了近年来关于MIC3的分子生物学特征、相关疫苗及其用于弓形虫病诊断方面的研究进展。

Microneme protein 3（MIC3） of Toxoplasma gondii is a secreted protein.MIC3 has high immunoreactivity,and plays an important role in recognization,adhesion and invasion for T.gondii to host cells.Studies on MIC3 of T.gondii will promote the development of diagnostics agents and vaccines to prevent T.gondii infection.Here,the research advances on molecular characterization of MIC3 and its potential applications on developing diagnosis mathods and vaccine were reviewed.