摘要
目的:提高难溶性药物大豆异黄酮的体外溶出度。方法:以聚乙烯吡咯烷酮(PVPK30)为载体,制备大豆异黄酮与载体不同比例的固体分散物及物理混合物,并测定药物的体外溶出度。结果:固体分散物的体外溶出度明显高于物理混合物及大豆异黄酮原料的体外溶出度,且随载体比例的增加而增大。结论:大豆异黄酮与载体比例为1:5的固体分散物可明显提高药物的体外溶出度。
To elevate the dissolution rate in vitro of soy isoflavones.Methods:Solid dispersions and physical mixtures with different proportion of soy isoflavones and polyvinylpyrrolidone (PVPk30) were respectively prepared and the dissolution rate in vitro of soy isoflavones was determined.Results:The dissolution rate of solid dispersions was obviously higher than physical mixtures; moreover, the dissolution rate increased with increasing of carrier.Conclusions:The dissolution rate of soy isoflavones-PVPr.30 solid dispersions with ratio of 1:5 can obviously elevate the dissolution rate in vitro of soy isoflavones.
出处
《承德医学院学报》
2012年第1期10-11,共2页
Journal of Chengde Medical University