ERCC1和EGFR表达与NSCLC生物学特征的关系

THE RELATIONSHIP BETWEEN ERCC1,EGFR EXPRESSION AND BIOCHARACTERISTICS OF NSCLC

目的:探讨切除修复交叉互补基因1(ERCC1)和表皮生长因子受体(EGFR)表达与非小细胞肺癌(NSCLC)生物学特征的关系。方法:应用免疫组织化学方法检测97例NSCLC患者癌组织及30例癌旁组织ERCC1、EGFR的表达情况,观察二者的表达与NSCLC生物学特征的关系。结果:ERCC1、EGFR在NSCLC中的阳性表达率分别为29.9%(29/97)和22.7%(22/97),均明显高于癌旁组织,差异具有统计学意义(P<0.05)。NSCLC中ERCC1表达与年龄有关(P<0.05),EGFR表达与性别和病理类型有关(P<0.05)。结论:NSCLC中ERCC1和EGFR的表达是判定化疗疗效和评估预后的重要指标。

Objective:To investigate the relationship between excision repair cross-complementary gene-1(ERCC1),epidermal growth factor receptor(EFGR) expression and biocharacteristics of non-small cell lung cancer(NSCLC).Methods:Immunohistochemical method was used to detect the expression of ERCC1 and EFGR in 97 cases NSCLC and 30 cases para-carcinoma tissues;and observe the relationship of their expression with biocharacteristics of NSCLC.Results:The positive expression rate of ERCC1 and EGFR in NSCLC were respectively 29.9%(29/97) and 22.7%(22/97),which were obviously higher than that of para-carcinoma tissues(P<0.05).In NSCLC,the expression of ERCC1 had relations with age(P<0.05),the expression of EGFR had relations with sex and pathological types(P<0.05).Conclusions:The expressions of ERCC1 and EGFR in NSCLC are important indexes to evaluate curative effects of chemotherapy and predict prognosis.